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World J Transplant. Jun 24, 2014; 4(2): 40-42
Published online Jun 24, 2014. doi: 10.5500/wjt.v4.i2.40
Published online Jun 24, 2014. doi: 10.5500/wjt.v4.i2.40
Organ assessment and repair centers: The future of transplantation is near
Bryan A Whitson, Division of Cardiac Surgery, The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Sylvester M Black, Division of Transplantation, The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Author contributions: Whitson BA and Black SM contributed equally to this works authorship and revision.
Correspondence to: Bryan A Whitson, MD, PhD, Division of Cardiac Surgery, The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, The Ohio State University Wexner Medical Center, N-813 Doan Hall, 410 W 10th Ave, Columbus, OH 43210, United States. bryan.whitson@osumc.edu
Telephone: +1-614-3667414 Fax: +1-614-2932020
Received: November 28, 2013
Revised: April 9, 2014
Accepted: April 16, 2014
Published online: June 24, 2014
Processing time: 234 Days and 0.3 Hours
Revised: April 9, 2014
Accepted: April 16, 2014
Published online: June 24, 2014
Processing time: 234 Days and 0.3 Hours
Abstract
Solid organ transplantation is limited by suitable donor organ availability and the geographic limitations that lead to prolonged ischemic times. Ex vivo organ perfusion is an evolving technology that enables assessment of organ function prior to transplantation. As a byproduct, overall out of body organ times are able to be extended. The future implications organ assessment and repair centers utilizing this technology are discussed.
Keywords: Organ transplantation; Ex vivo organ perfusion; Lung; Liver; Kidney; Heart
Core tip: Regional organ assessment and repair centers will build upon normo-thermic ex vivo organ perfusion technology, which in turn provides a potential platform to assess, repair and eventually modify donor organs.