Review
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World J Transplant. Dec 24, 2013; 3(4): 91-98
Published online Dec 24, 2013. doi: 10.5500/wjt.v3.i4.91
Role of IL-10 in the progression of kidney disease
Inna Sinuani, Ilia Beberashvili, Zhan Averbukh, Judith Sandbank
Inna Sinuani, Judith Sandbank, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, Israel
Ilia Beberashvili, Zhan Averbukh, Nephrology Division, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, Israel
Author contributions: Sinuani I, Sandbank J and Beberashvili I designed the research, analyzed the data and performed the search of the literature; Sinuani I wrote the paper; Averbukh Z critically revised the paper.
Correspondence to: Inna Sinuani, PhD, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Haim Levanon 55, Zerifin 70300, Israel. sinuanii@asaf.health.gov.il
Telephone: +972-8-9779800 Fax: +972-8-9779801
Received: May 23, 2013
Revised: September 22, 2013
Accepted: October 11, 2013
Published online: December 24, 2013
Processing time: 221 Days and 21.8 Hours
Abstract

Interleukin-10 (IL-10), a cytokine with anti-inflammatory and immunomodulatory functions, regulates the biology of B and T cells. The present review describes the role of IL-10 in normal renal physiology, during acute kidney injury and in the development of chronic renal failure. We further discuss IL-10-induced cellular and molecular pathways and their link to the progression of kidney injury.

Keywords: Transforming growth factor-β; Cystatin C; Interleukin-10 receptor; End-stage renal disease; Mesangial cell proliferation; Epithelial-to-mesenchymal transition; Allograft rejection

Core tip: Interleukin-10 (IL-10) gene expression and IL-10-induced signaling pathways have an important role in the regulation and maintenance of normal renal function. Accumulating evidence further demonstrates that abnormal IL-10 expression whether transient or prolonged, as well as interactions with other growth factors as a response to diverse stimuli is linked to the appearance and progression of a variety of kidney disorders. It has been thus suggested that selective targeting of IL-10 expression and IL-10-related pathways may provide the therapeutic features to many kidney diseases.