Semash K, Dzhanbekov T. Large-for-size syndrome prophylaxis in infant liver recipients with low body mass. World J Transplant 2025; 15(1): 99452 [DOI: 10.5500/wjt.v15.i1.99452]
Corresponding Author of This Article
Konstantin Semash, MD, PhD, Consultant Physician-Scientist, Surgeon, Department of Mini-Invasive Surgery, National Children's Medical Center, Parkent Street 294, Tashkent 100171, Toshkent, Uzbekistan. doctorsemash@gmail.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Mar 18, 2025; 15(1): 99452 Published online Mar 18, 2025. doi: 10.5500/wjt.v15.i1.99452
Large-for-size syndrome prophylaxis in infant liver recipients with low body mass
Konstantin Semash, Timur Dzhanbekov
Konstantin Semash, Timur Dzhanbekov, Department of Mini-Invasive Surgery, National Children's Medical Center, Tashkent 100171, Toshkent, Uzbekistan
Co-first authors: Konstantin Semash and Timur Dzhanbekov.
Author contributions: Semash K contributed to project administration, supervision, figures and tables; Dzhanbekov T contributed to conceptualization, methodology; Dzhanbekov T and Semash K contributed to writing-original draft.
Conflict-of-interest statement: All the authors declare no actual or potential conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Konstantin Semash, MD, PhD, Consultant Physician-Scientist, Surgeon, Department of Mini-Invasive Surgery, National Children's Medical Center, Parkent Street 294, Tashkent 100171, Toshkent, Uzbekistan. doctorsemash@gmail.com
Received: July 23, 2024 Revised: September 27, 2024 Accepted: October 25, 2024 Published online: March 18, 2025 Processing time: 127 Days and 5.5 Hours
Abstract
Transplantation of the left lateral section (LLS) of the liver is now an established practice for treating advanced diffuse and unresectable focal liver diseases in children, with variants of the LLS primarily used in infants. However, the surgical challenge of matching the size of an adult donor's graft to the volume of a child's abdomen remains significant. This review explores historical developments, various approaches to measuring the required functional liver mass, and techniques to prevent complications associated with large-for-size grafts in infants.
Core Tip: Transplantation of the left lateral section is a well-established treatment for advanced liver diseases in children, particularly infants. This review highlights the ongoing challenge of matching adult donor grafts to the smaller abdominal capacity of pediatric recipients. It also discusses the evolution of surgical approaches, methods for accurately assessing required liver mass, and strategies for mitigating complications related to large-for-size grafts.
