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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study
Geisiane Custodio, Andrew Maykon Massutti, Aline Caramori, Taynara Gonçalves Pereira, Augusto Dalazen, Gabriela Scheidt, Ludmilla Thomazini, Cristiane Bauermann Leitão, Tatiana Helena Rech
Geisiane Custodio, Department of Intensive Care Unit, Hospital Santa Isabel, Blumenau-Santa Catarina CEP-89010906, Brazil
Andrew Maykon Massutti, Aline Caramori, Taynara Gonçalves Pereira, Augusto Dalazen, Transplant Division, Hospital Santa Isabel, Blumenau-Santa Catarina CEP-89010906, Brazil
Gabriela Scheidt, School of Medicine, Universidade Regional de Blumenau (FURB), Blumenau-Santa Catarina CEP-89010906, Brazil
Ludmilla Thomazini, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, Brazil
Cristiane Bauermann Leitão, Departement of Endocrinology, Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, Rio Grande do Sul, Brazil
Tatiana Helena Rech, Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Division of Intensive Care Medicine, Porto Alegre 90035-903, Brazil
Author contributions: Custodio G participated in the study design, collection and interpretation of data, statistical analysis, and drafting of the manuscript; Massutti AM and Caramori A performed all liver transplantations; Pereira TG, Dalazen A, Scheidt G, and Thomazini L were involved in data collection; Leitão CB participated in the study conception and design, interpretation of data, and statistical analysis; Rech T contributed to the study conception and design, interpretation of data, statistical analysis, and drafting the manuscript; All authors reviewed and edited the manuscript. Rech TH is the guarantor of this work and, as such, had complete access to all data, with full responsibility for the integrity of the data and accuracy of analysis.
Institutional review board statement: The study was approved by the reference Ethics Committee at the Universidade Federal Rio Grande do Sul (PROPESQ UFRGS, project No. 5.526.176), Brazil. The study adheres to the guidelines set forth by the Helsinki Declaration, as well as to local standards and Brazilian legislation.
Informed consent statement: The Ethics Committee did not require informed consent due to the retrospective design and the anonymization of donors and recipients prior to analysis.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Consent was not obtained, but the potential benefits of sharing this data outweigh the potential harms, as it may bring improvement to transplant patients and not pose a direct risk to patients. The Term of Commitment for Data Usage used will be attached. Available in
Geisiane_c@yahooo.com.br.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Geisiane Custodio, PhD, Attending Doctor, Professor, Researcher, Department of Intensive Care Unit, Hospital Santa Isabel, Rua Floriano Peixoto 300, Centro, Blumenau-Santa Catarina CEP-89010906, Brazil.
geisiane_c@yahoo.com.br
Received: November 9, 2023
Peer-review started: November 9, 2023
First decision: November 29, 2023
Revised: December 13, 2023
Accepted: January 12, 2024
Article in press: January 12, 2024
Published online: March 18, 2024
Processing time: 126 Days and 16.9 Hours
BACKGROUND
Prolonged donor hepatectomy time may be implicated in early and late complications of liver transplantation.
AIM
To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients, mainly early allograft dysfunction.
METHODS
This multicenter retrospective study included brain-dead donors and adult liver graft recipients. Donor-recipient matching was obtained through a crossover list. Clinical and laboratory data were recorded for both donors and recipients. Donor hepatectomy, cold ischemia, and warm ischemia times were recorded. Primary outcome was early allograft dysfunction. Secondary outcomes included need for retransplantation, length of intensive care unit and hospital stay, and patient and graft survival at 12 months.
RESULTS
From January 2019 to December 2021, a total of 243 patients underwent a liver transplant from a brain-dead donor. Of these, 57 (25%) developed early allograft dysfunction. The median donor hepatectomy time was 29 (23–40) min. Patients with early allograft dysfunction had a median hepatectomy time of 25 (22–38) min, whereas those without it had a median time of 30 (24–40) min (P = 0.126).
CONCLUSION
Donor hepatectomy time was not associated with early allograft dysfunction, graft survival, or patient survival following liver transplantation.
Core Tip: This study aims to evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients. This is a multicenter retrospective study that included brain-dead donors and adult liver graft recipients. A total of 243 patients underwent liver transplantation form brain-dead donors. The median duration of donor hepatectomy was 29 (23–40) min. Patients with early allograft dysfunction had a median hepatectomy time of 25 (22-38) min, while those without had a median time of 30 (24–40) min (P = 0.126). Duration of donor hepatectomy was not associated with early allograft dysfunction, graft survival, or patient survival following liver transplantation.
