Okumura K, Grace H, Sogawa H, Yamanaga S. Acute kidney injury and the compensation of kidney function after nephrectomy in living donation. World J Transplant 2022; 12(8): 223-230 [PMID: 36159072 DOI: 10.5500/wjt.v12.i8.223]
Corresponding Author of This Article
Kenji Okumura, MD, Doctor, Department of Surgery, Westchester Medical Center/New York Medical College, 100 Woods Road, Valhalla, NY 10595, United States. kenji.okumura@wmchealth.org
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Kenji Okumura, Hiroshi Sogawa, Department of Surgery, Westchester Medical Center/New York Medical College, Valhalla, NY 10595, United States
Holly Grace, Department of Surgery, New York Medical College, Valhalla, NY 10595, United States
Shigeyoshi Yamanaga, Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto 861-8520, Japan
Author contributions: Okumura K and Yamanaga S designed the study, wrote the initial draft of the manuscript; Okumura K, Grace H, Sogawa H and Yamanaga S critically reviewed and revised the manuscript; and all authors approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kenji Okumura, MD, Doctor, Department of Surgery, Westchester Medical Center/New York Medical College, 100 Woods Road, Valhalla, NY 10595, United States. kenji.okumura@wmchealth.org
Received: January 16, 2022 Peer-review started: January 16, 2022 First decision: March 16, 2022 Revised: March 27, 2022 Accepted: August 6, 2022 Article in press: August 6, 2022 Published online: August 18, 2022 Processing time: 213 Days and 23.7 Hours
Abstract
Acute kidney injury (AKI) incidence is growing rapidly, and AKI is one of the predictors of inpatient mortality. After nephrectomy, all the patients have decreased kidney function with AKI and recover from AKI. However, the characteristic and behavior of AKI is different from usual AKI and compensatory kidney function has been well known in the postoperative setting, especially in living donors. In this review, we have focused on the compensation of kidney function after nephrectomy in living donors. We discuss factors that have been identified as being associated with kidney recovery in donors including age, sex, body mass index, remnant kidney volume, estimated glomerular filtration rate, and various comorbidities.
Core Tip: Acute kidney injury (AKI) incidence is growing rapidly, and AKI is one of the predictors of inpatient mortality. The characteristic and behavior of AKI is different from usual AKI and compensatory kidney function has been well known in the postoperative setting, especially in living donors. In this review, we have focused on the compensation of kidney function after nephrectomy in living donors. We discuss factors of compensation of kidney function after nephrectomy.
