Published online Jun 18, 2022. doi: 10.5500/wjt.v12.i6.131
Peer-review started: January 7, 2022
First decision: February 21, 2022
Revised: February 25, 2022
Accepted: May 22, 2022
Article in press: May 22, 2022
Published online: June 18, 2022
Patients with a history of primary brain tumors can be eligible for organ donation under extended criteria. The risk assessment of tumor transmission via organ transplant in primary brain tumors is primarily based on the assessment of tumor histotype and grade. Previous surgeries, chemo-/radiotherapy, and ventriculo-peritoneal shunt placement can lead to a disruption of the blood-brain barrier, concurring to an increase in the transmission risk.
To investigate the role of tumor transmission risk factors in donors with oligoden
We searched PubMed and EMBASE databases for studies reporting extraneural spreading of oligoden
Data on a total of 157 patients were retrieved. The time from the initial diagnosis to metastatic spread ranged from 0 to 325 mo in patients with oligodendrogliomas and 0 to 267 mo in those with astrocytomas. Respectively, 19% and 39% of patients with oligodendroglioma and astrocytoma did not receive any adjuvant therapy. The most frequent metastatic sites were bone, bone marrow, and lymph nodes. The lungs and the liver were the most commonly involved visceral sites. There was no significant correlation between the occurrence of multiple metastases and the administration of adjuvant chemo-/radiotherapy. Patients who developed intracranial recurrences/metastases had a significantly longer extraneural metastasis-free time compared to those who developed extraneural metastases in the absence of any intra- central nervous system spread.
A long follow-up time does not exclude the presence of extraneural metastases. Therefore, targeted imaging of bones and cervical lymph nodes may improve safety in the management of these donors.
Core Tip: Recognized risk factors of tumor transmission from donors with a history of primary brain tumors are previous surgery, chemotherapy,and radiotherapy. We performed a systematic review of the literature on oligodendroglioma and astrocytomas with extraneural metastases, aiming to clarify the role of tumor transmission risk factors. We searched PubMed and EMBASE databases for studies reporting extraneural spreading of these gliomas. Performed treatments do not seem to impact on the timing of metastatic spread, and a long follow-up time does not exclude extraneural spread. Targeted imaging of bones and cervical lymph nodes may improve safety in the management of these donors.