Mohamed MM, Daoud A, Quadri S, Casey MJ, Salas MAP, Rao V, Fülöp T, Soliman KM. Hypertension and obesity in living kidney donors. World J Transplant 2021; 11(6): 180-186 [PMID: 34164293 DOI: 10.5500/wjt.v11.i6.180]
Corresponding Author of This Article
Karim M Soliman, MD, MSc, Assistant Professor, Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas St., Charleston, SC 29425, United States. drkarimsoliman@gmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Jun 18, 2021; 11(6): 180-186 Published online Jun 18, 2021. doi: 10.5500/wjt.v11.i6.180
Hypertension and obesity in living kidney donors
Mahmoud M Mohamed, Ahmed Daoud, Syed Quadri, Michael J Casey, Mariah Aurora Posadas Salas, Vinaya Rao, Tibor Fülöp, Karim M Soliman
Mahmoud M Mohamed, Department of Medicine, Division of Nephrology, University of Tennessee, Memphis, TN 38163, United States
Ahmed Daoud, Department of Medicine, Division of Nephrology, Cairo University, Cairo 11562, Egypt
Syed Quadri, Michael J Casey, Mariah Aurora Posadas Salas, Vinaya Rao, Tibor Fülöp, Karim M Soliman, Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, United States
Tibor Fülöp, Medicine Service, Ralph H. Johnson VA Medical Center, Charleston, SC 29401, United States
Author contributions: Mohamed MM wrote the initial draft; Daoud A, Salas MAP, Rao V and Casey MJ reviewed the manuscript; Quadri S participated in writing; Fülöp T and Soliman KM participated in writing and reviewed the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Karim M Soliman, MD, MSc, Assistant Professor, Department of Medicine, Division of Nephrology, Medical University of South Carolina, 96 Jonathan Lucas St., Charleston, SC 29425, United States. drkarimsoliman@gmail.com
Received: January 23, 2021 Peer-review started: January 25, 2021 First decision: February 14, 2021 Revised: February 26, 2021 Accepted: May 22, 2021 Article in press: May 22, 2021 Published online: June 18, 2021
Abstract
Over the past few decades, the shortage in the kidney donor pool as compared to the increasing number of candidates on the kidney transplant waitlist led to loosening of kidney donors’ acceptance criteria. Hypertension and obesity represent risk factors for chronic kidney disease, both in native kidneys and those in kidney transplant recipients. While great progress has been made in kidney transplantation from living donors to benefit the recipient survival and quality of life, progress has been slow to fully risk-characterize the donors. This review critically reassesses the current state of understanding regarding the risk of end-stage kidney disease in those donors with obesity, hypertension or both. Accurate risk assessment tools need to be developed urgently to fully understand the risk glomerular filtration rate compensation failure in the remaining kidney of the donors.
Core Tip: Hypertension and obesity represent risk factors for chronic kidney disease, both in native kidneys and those in kidney transplant recipients. While great progress has been made in kidney transplantation from living donors to benefit the recipient survival and quality of life, progress has been slow to fully risk-characterize the donors. This review critically reassesses the current state of understanding regarding the risk of end-stage kidney disease in those donors with obesity, hypertension or both.
