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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Interstitial lung disease in rheumatoid arthritis: Current concepts in pathogenesis, diagnosis and therapeutics
Eva M Olivas-Flores, Hospital General Regional 180 Instituto Mexicano del Seguro Social (IMSS), Tlajomulco 45640, Mexico
David Bonilla-Lara, Jorge I Gamez-Nava, Alberto D Rocha-Muñoz, Laura Gonzalez-Lopez, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Jalisco 44280, Mexico
Jorge I Gamez-Nava, Hospital de Especialidades Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco 44340, Mexico
Laura Gonzalez-Lopez, Hospital General Regional 110 Departamento de Medicina Interna-Reumatologia, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco 48520, Mexico
Author contributions: All the authors equally contributed to this work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Laura Gonzalez-Lopez, MD, MSc, PhD, Hospital General Regional 110 Departamento de Medicina Interna-Reumatologia, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco 48520, Mexico. dralauragonzalez@prodigy.net.mx
Telephone: +52-33-38541369
Received: July 21, 2014
Peer-review started: July 22, 2014
First decision: July 22, 2014
Revised: September 27, 2014
Accepted: December 10, 2014
Article in press: December 10, 2014
Published online: March 12, 2015
Processing time: 240 Days and 3.9 Hours
Peer-review started: July 22, 2014
First decision: July 22, 2014
Revised: September 27, 2014
Accepted: December 10, 2014
Article in press: December 10, 2014
Published online: March 12, 2015
Processing time: 240 Days and 3.9 Hours
Core Tip
Core tip: This review analyzes current evidence regarding the epidemiology, pathogenesis, diagnosis and treatment of interstitial lung disease associated with rheumatoid arthritis (RA-ILD). Data regarding differences in the prevalence of RA-ILD in different populations are presented. Updates regarding the pathogenesis of RA-ILD, including genetics, environmental factors, cytokines and autoantibodies, are presented. The paper also reviews the different tests used to diagnose RA-ILD, describes RA-ILD treatment, and discusses studies that were designed to identify a therapeutic response to immunosuppressive drugs or biological agents.