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World J Rheumatol. Feb 18, 2025; 12(2): 103837
Published online Feb 18, 2025. doi: 10.5499/wjr.v12.i2.103837
Antiphospholipid syndrome in pregnancy: A comprehensive review
Prosper Akankwasa, Jackson Kakooza, John Katongole, Esther Namutosi, Catherine Lewis, Emmanuel Okurut
Prosper Akankwasa, John Katongole, Esther Namutosi, Emmanuel Okurut, Department of Obstetrics and Gynecology, Kampala International University Western Campus, Ishaka Bushenyi, Uganda
Jackson Kakooza, Department of Surgery, Kampala International University Western Campus, Ishaka Bushenyi, Uganda
Catherine Lewis, Department of Surgery, St. Joseph's Kitovu Hospital, Masaka, Uganda
Catherine Lewis, Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States
Co-first authors: Prosper Akankwasa and Jackson Kakooza.
Author contributions: Akankwasa P and Kakooza J contributed equally to this work and conceived the idea, performed the research and literature review; Lewis C performed critical revision of the manuscript and made the figure and table; Akankwasa P, Kakooza J, Katongole J, Namutosi E, Lewis C, and Okurut E drafted the manuscript; all authors gave final approval of the version to be published
Conflict-of-interest statement: The authors declare that there is no conflict of interest regarding the publication of this paper.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Catherine Lewis, MD, PhD, Department of Surgery, St. Joseph's Kitovu Hospital, PO BOX 524, Masaka, Uganda. cathymdphd@gmail.com
Received: December 4, 2024
Revised: January 17, 2025
Accepted: January 23, 2025
Published online: February 18, 2025
Processing time: 78 Days and 2.5 Hours
Core Tip

Core Tip: Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder associated with pregnancy complications primarily due to thrombotic events. The diagnosis of APS involves criteria in laboratory, macrovascular, microvascular, obstetric, cardiac, and hematological domains. The cardinal goal of management during pregnancy focuses on prevention of thrombotic events and pregnancy complications.