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©The Author(s) 2015.
World J Psychiatr. Mar 22, 2015; 5(1): 126-137
Published online Mar 22, 2015. doi: 10.5498/wjp.v5.i1.126
Published online Mar 22, 2015. doi: 10.5498/wjp.v5.i1.126
Table 1 Mood Spectrum Structured Interview and Mood Spectrum Self-Report version studies
| Ref. | Subjects | Design | Diagnostic criteria | Instruments | Results |
| Fagiolini et al[10] | 491 (141 students, 116 gastrointestinal pts, 112 pts with BPD, 122 pts with recurrent MDEs) | Validation study (Italy) | DSM-IV | SCID-I, SCI-MOODS | Good discriminant validity and internal consistency |
| Dell’Osso et al[11] | 41 (21 pts with MDEs or BPD vs 20 controls) | Validation study (Italy) | DSM-IV | SCID-I, SCI-MOODS, MOODS-SR | Good reliability of the self-report version (MOODS-SR) of the SCI-MOODS. Intraclass correlation coefficients ranged from 0.88 to 0.97 |
| Veltri et al[34] | 91 pts with TMD vs 26 TMD-free subjects | Open study (Italy) | Helkimo’s Clinical Dysfunction Index (CDI), MOODS-SR | Total scores of depressive domains significantly higher in moderate or severe dysfunctional than in TMD-free and mild dysfunctional pts | |
| Cassano et al[18] | 213 (117 pts with recurrent MDEs in remission and 106 pts with BP-I) | Open study (Italy) | DSM-IV | MINI, SCI-MOODS | Patients with recurrent UP depression endorsed a substantial number of manic/hypomanic symptoms over their lifetimes |
| Manfredini et al[35] | 85 subjects (34 bruxers vs 51 non-bruxers) | Open Study (Italy) | DSM-IV | MOODS-SR, PAS-SR | Significant differences between bruxers and controls emerged for the presence of both depressive and manic symptoms in MOODS-SR |
| Manfredini et al[36] | 131 subjects screened for temporomandibular disorder (TMD) | Open study (Italy) | DSM-IV | MOODS-SR, PAS-SR, assessment for TMD | Significantly higher prevalence of both mood and panic-agoraphobic symptoms in myofascial pain pts than in the other diagnostic groups (TMD-free, disc displacement and joint disorders) |
| Manfredini et al[37] | 20 pts with myofascial pain, 18 pts with temporomandibular joint pain-TMJ, 22 pts with combined pain vs 25 pts with non-painful TMD vs 29 TMD-free subjects | Open study (Italy) | DSM-IV | MOODS-SR, PAS-SR, assessment for TMD | Patients with painful TMD scored significantly higher than comparison groups in all MOODS-SR depressive domains |
| Cassano et al[19] | 39 pts with Borderline PD + BPD vs 21 pts with Borderline PD | Open study (Italy) | DSM-IV | SCID-I, MOODS-SR, SCID-II | Lifetime manic-hypomanic mood dysregulations correlated with psychotic spectrum features in borderline patients |
| Benvenuti et al[45] | 103 (70 pts with BP-I, 24 pts with BP-II, 4 pts with SA, 5 pts with BPD-NOS | Open study (United States) | DSM-IV | SCID-I, MOODS-SR, W-SAS, PAS-SR | WSAS scores on current depressive, manic, and panic spectrum total scores showed a highly significant “depressive spectrum” effect |
| Dell’Osso et al[30] | 92 pts with Rheumatoid Arthritis | Open study (Italy) | DSM-IV | HAQ, MOS-SF36, MOODS-SR | Lifetime mood depressive spectrum was related with impaired HRQoL levels |
| Manfredini et al[38] | 105 controls with bruxing behaviors | Open study (Italy) | DSM-IV | MOODS-SR | Prevalence of mood psychopathology was significantly higher in bruxers. Significant differences between bruxers and non-bruxers emerged in total MOODS-SR scores |
| Koukopoulos et al[57] | 24 pts with Unipolar Depression vs 15 pts with BP-II | Open study (Japan) | DSM-IV | SCI-MOODS | Patients with BP-II disorder tended to show apparently quick disappearance of depressive symptoms |
| Ghouse et al[15] | 71 (49 with MDEs or BPD or GAD, 22 controls) | Validation study (Spanish) | DSM-IV | SCID-I, BDI, MOODS-SR, Clinician-Administered Rating Scale for Mania | MOODS-SR good internal consistency and test-retest reliability. Significant positive correlations between depressive sub-domains and BDI and between manic-hypomanic subdomains and CARS for Mania |
| Piccinni et al[32] | 92 pts with Rheumatoid Arthritis | Open study (Italy) | DSM-IV | MOS-SF36, MOODS-SR, PAS-SR | Significant worsening of all MOS SF-36 scores related to higher scores of the depressive domains of MOODS-SR |
| Benvenuti et al[20] | 90 (25 pts with Borderline PD, 16 pts with BPD, 19 pts with MDE, 30 controls) | Open study (Spanish) | DSM-IV | SCID-I, MOODS-SR | No statistical significance for any (sub) domain considered between patients with BPD and Bipolar Disorder |
| Manfredini et al[39] | 47 subjects (17 pts with BPD, 14 pts with MDEs, 16 controls) | Open study (Italy) | DSM-IV | SCID-I, SCI-MOODS-SR | Allopregnanolone/progesterone levels correlate with mixed features |
| Berrocal et al[16] | 598 pts with MDE | Open study (Italy + United States) | DSM-IV | SCID-I, MOODS-SR | Central role of depressed mood, psychomotor retardation and suicidality. The factors “Drug/Illness related depression”, “Psychotic features” and the neurovegetative dysregulation were identified |
| Cassano et al[17] | 617 pts with BPD | Open study (Italy + United States) | DSM-IV | SCID-I, MOODS-SR | 9 factors initially identified, 5 of them (Psychomotor Activation, Mixed Instability, Spirituality/Mysticism/Psychoticism, Mixed Irritability, Euphoria) subsequently retained |
| Dell’Osso et al[27] | 130 (65 pts with PTSD vs 65 controls) | Open study (Italy) | DSM-IV | SCID-I, MOODS-SR | Statistically significant and positive associations were found between the presence of manic/hypomanic and depressive symptoms and the likelihood of suicidal ideation or attempts |
| Dell’Osso et al[29] | 167 pts with fibromyalgia | Open study (Italy) | DSM-IV | SCID-I, MOS-SF36, FIQ, MOODS-SR | A high rate of lifetime manic symptoms was related to the Pain Visual Analogic Scale of the FIQ and the FIQ total scores and to the “bodily pain”, and to the physical and mental component scores of the MOS SF-36 |
| Mauri et al[41] | 316 pts with MDEs | Depression Phenotype Study: Randomized (Italy + United States) | DSM-IV | SCID-I, MOODS-SR, HAM-D | In patients who reached remission from an MDE according to the Hamilton Rating Scale for Depression, scores on the depressive component of the MOODS-SR predicted relapses in the subsequent 6 mo |
| Benazzi et al[51] | 222 pts with MDEs | Depression Phenotype Study: Randomized (Italy + United States) | DSM-IV | SCID-I, MOODS-SR | Association between the manic/hypomanic component of the MOODS-SR and the polymorphisms of the 5-HTTLPR was moderated by gender |
| Miniati et al[42] | 312 pts with MEDs (78 with a history of emotional/physical abuse, EPA) | Depression Phenotype Study: Randomized (Italy + United States) | DSM-IV | SCID-I, SCID-II, HRSD, QIDS, MOODS-SR | Patients with a history of EPA did not differ from those without on HAM-D scores at baseline. The two groups differed on factors: “dep. Mood”, “psychomotor retardation”, “drug and illness-related depression”, and “neurovegetative symptoms” |
| Frank et al[44] | 226 pts with MDEs | Depression Phenotype Study: Randomized (Italy + United States) | DSM-IV | SCID-I, HAM-D, Q-LES-Q, WSAS, MOODS-SR, PAS-SR | Poor quality of life associated with the MOODS-SR factors “depressive mood” and “psychotic features” and the PAS-SR factors “separation anxiety” and “loss sensitivity”. Functional impairment was associated with the MOODS-SR factor “psychomotor retardation” and the PAS-SR factor “fear of losing control” |
| Dell’Osso et al[28] | 48 (25 pts with PTSD vs 23 controls) | Open study (Italy) | DSM-IV | SCID-I, IES, MOODS-SR | PTSD pts showed a significant decrease in TSPO density. TSPO density correlated with the number of lifetime manic/hypomanic spectrum symptoms |
| Bazzichi et al[31] | 110 (60 pts with fibromyalgia vs 50 pts with Rheumatoid Arthritis) | Open study (Italy) | DSM-IV | MOODS-SR (OTHERS?) | FM pts showed significantly higher scores than RA patients in “mood depressive”, “cognition depressive” domains and in total depressive component |
| Miniati et al[43] | 318 pts with MDEs | Depression Phenotype Study: Randomized (Italy + United States) | DSM-IV | SCID-I, HAM-D, MOODS-SR, PAS-SR, SHY-SR | Participants with lower scores on the MOODS-SR “psychomotor activation” factor experienced more rapid remission with SSRI |
| Fagiolini et al[46] | 291 pts with MDEs | Depression Phenotype Study: Randomized (Italy + United States) | DSM-IV | SCID-I, SCID-II, HRSD, QIDS, MOODS-SR | Compared to low scorers, participants with high scores on the LPR factor had greater severity of depression and more bipolarity indicators |
| Dell’Osso et al[24] | 103 (53 pts with complicated grief vs 50 controls) | Open study (Italy) | DSM-IV | SCID-I, ICG, ASA-27, W-SAS, MOODS-SR | Patients with CG reported significantly higher scores on the MOODS-SR, ASA-27, and WSAS with respect to controls. The scores on the ASA-27 were significantly associated with the MOODS-SR depressive and manic components |
| Apfelbaum et al[22] | 50 pts with complicated grief | Open study (Italy) | DSM-IV | SCID-I, ICG, MOODS-SR | MOODS-SR depressive and rhythmicity/vegetative items were associated with increased suicidal ideation and attempts, while sub-threshold manic items with suicidal ideation |
| Rucci et al[52] | 1158 pts with MDEs or BPD | Open study (Italy + United States) | DSM-IV | SCID-I, MOODS-SR | MOODS-SR psychomotor activation factor identified subgroups with an increasing likelihood of bipolar disorder diagnosis |
| Dell’Osso et al[25] | 116 (66 pts with PTSD, 22 pts with complicated grief, 28 pts with PTSD+complicated grief) | Open study (Italy) | SCID-I, ICG, ASA-27, W-SAS, MOODS-SR | Patients with CG+PTSD or PTSD alone reported significantly higher scores on the manic component of the MOODS-SR | |
| Dell’Osso et al[23] | 389 subjects (156 with Mood Disorders, 54 pts with Panic Disorder, 79 pts with schizophrenia, 100 controls) | Open study (Italy) | DSM-IV-TR | BPRS, OBS-SR, MOODS-SR, SCID-I | Sexual obsessions more frequent in schizophrenia (54.4%), followed by mood disorders (35.9%), and independently associated with all aspects of suicidal behaviors |
| Hardoy et al[40] | 1066 pregnant women | Prospective Study (Italy) | DSM-IV | SCID-I, EPDS, MOODS-SR | The prevalence of suicidality in women who had MmD during pregnancy was 26.4% and 34.1%, assessed with the MOODS-SR and the EPDS, respectively, while it was 18.4% (MOODS-SR) and 30.6% (EPDS) during the postpartum period |
| Berrocal et al[21] | 63 pts with MDE, BPD, Cluster B PD, comorbid BPD and PD-B | Open Study (United States) | DSM-IV | MINI and SCID II, MOODS-SR, BI, TEMPS-A and IPDE | BD+PD-B pts showed a more severe type of emotional dysregulation. Patients with BD+PD-B comorbidity had an earlier onset and more severity in suicide attempts, hospitalizations and self-harm behaviors |
| Dell’Osso et al[26] | 475 students | Open study (Italy) | DSM-IV | MOODS-SR, TALS-SR (Others?) | Significantly higher MOODS-SR domain scores were found in PTSD survivors compared to those without. The mood depressive, cognition depressive and energy manic MOODS-SR domains were associated with an increased likelihood of PTSD |
| Rucci et al[14] | 139 (52 pts with BP-I, 32 pts with BP-II, 17 pts with BPD-NOS vs 38 controls) | Open Study (United States) | DSM-IV | MOODS-SR, SCID-I, GAF | BPD pts scored significantly higher than controls on the total MOODS-SR scores and all sub-domains. Comparisons across BD subtypes revealed statistically significant higher scores among BD I, BD II and BD NOS only for the total MOOD-SR scores and for mood mania and energy domains |
- Citation: Benvenuti A, Miniati M, Callari A, Mariani MG, Mauri M, Dell’Osso L. Mood Spectrum Model: Evidence reconsidered in the light of DSM-5. World J Psychiatr 2015; 5(1): 126-137
- URL: https://www.wjgnet.com/2220-3206/full/v5/i1/126.htm
- DOI: https://dx.doi.org/10.5498/wjp.v5.i1.126