Relationship between inflammatory factors, lactic acid levels, acute skin failure, bad mood, and sleep quality

Table 1 General data comparison of patients

Group	Age (years)	Sex		BMI (kg/m2)
		Male	Female
ASF group (n = 35)	56.60 ± 11.03	18	17	22.34 ± 2.36
Non-ASF group (n = 115)	56.35 ± 10.68	64	51	22.17 ± 2.40
t/χ2	-0.121	0.193		-0.362
P value	0.904	0.660		0.718

ASF: Acute skin failure; BMI: Body mass index.

Table 2 Comparison of inflammatory factors and blood lactic acid levels between the acute skin failure and non-acute skin failure groups

Group	IL-6 (pg/L)	CRP (mg/mL)	TNF-α (ng/mL)	Lactic acid (mmol/L)
ASF group (n = 35)	298.65 ± 48.65	19.60 ± 4.10	382.11 ± 43.56	8.42 ± 2.32
Non-ASF group (n = 115)	268.66 ± 33.66	15.30 ± 2.96	339.66 ± 34.56	5.70 ± 1.27
t	-17.923	-5.828	-5.971	-8.989
P value	< 0.001	< 0.001	< 0.001	< 0.001

ASF: Acute skin failure; IL-6: Interleukin-6; CRP: C-reactive protein; TNF-α: Tumor necrosis factor α.

Table 3 Comparison of skin mottling score and modified early warning scores between the acute skin failure and non-acute skin failure groups

Group	SMS (points)	MEWS (points)
ASF group (n = 35)	0 (0, 1)	9.34 ± 1.92
Non-ASF group (n = 115)	3 (2, 3)	6.48 ± 1.96
t/U	-7.982	-7.597
P value	< 0.001	< 0.001

ASF: Acute skin failure; MEWS: Modified early warning score; SMS: Skin mottling score.

Table 4 Comparison of self-rating anxiety scale, self-rating depression scale, and Pittsburgh sleep quality index scores between the acute skin failure group and non-acute skin failure group

Group	SAS (points)	SDS (points)	PSQI (points)
ASF group (n = 35)	61.63 ± 12.03	60.17 ± 12.64	14.23 ± 3.94
Non-ASF group (n = 115)	53.71 ± 12.48	52.27 ± 12.64	8.69 ± 2.46
t	-3.314	-3.339	-10.003
P value	< 0.001	< 0.001	< 0.001

ASF: Acute skin failure; SAS: Self-rating anxiety scale; SDS: Self-rating depression scale; PSQI: Pittsburgh sleep quality index.