Repetitive transcranial magnetic stimulation guided by event-related potential P300 application in schizophrenia

Table 1 Patient demographics

Group	5 Hz	10 Hz	15 Hz	χ2/F	P value
Gender (male/female)	21/21	21/21	21/21	2.351	0.382
Age (year)	45.2 ± 9.5	44.8 ± 7.9	45.4 ± 9.7	1.736	0.561
Education (year)	9.9 ± 4.7	9.6 ± 4.7	10.1 ± 5.2	0.827	0.837
Disease course (year)	7.2 ± 2.5	9.4 ± 2.2	8.4 ± 2.3	0.911	0.920
Drug dose (mg/day)	260.5 ± 24.3	270.5 ± 38.3	268.2 ± 29.4	2.410	0.991

Table 2 Scale for Assessment of Negative Symptoms score

Group	n	SANS score
		Before treatment	After treatment
5 Hz	42	48.3 ± 15.9	47.2 ± 14.7
10 Hz	42	47.9 ± 16.1	40.0 ± 16.8a
15 Hz	42	50.1 ± 19.4	49.4 ± 18.9
F		0.014	1.614
P value		0.979	0.219

^aP < 0.05, compared with the same group before treatment, t = 6.075.

SANS: Scale for Assessment of Negative Symptoms.

Table 3 Changes in P300 of the three groups of patients before and after repetitive transcranial magnetic stimulation

Groups	n	Latency period (millisecond)		Amplitude (μV)
		Before treatment	After treatment	Before treatment	After treatment
5 Hz	42	334.4 ± 60.1	337.1 ± 66.1	5.3 ± 2.1	5.7 ± 2.5
10 Hz	42	337.9 ± 59.9	331.5 ± 69.2	5.0 ± 2.1	7.9 ± 3.1a
15 Hz	42	324.9 ± 62.0	321.4 ± 63.1	5.8 ± 2.7	5.9 ± 2.3

^aP < 0.05, compared with the same group before treatment, t = 5.451.

Table 4 Regression analysis of factors affecting rehabilitation in patients in the 10 Hz group

Dependent variable	Unstandardized		Typical coefficient	t	P value	R	R2	ΔR2	SEE
	B	SE
Constant	3.301	0.358		7.801	0.001	0.309	0.102	0.089	2.794
Age	0.179	0.035	0.166	4.955	0.000	-	-	-	-
Disease course	0.111	0.024	0.123	4.018	0.013	-	-	-	-

SE: Standard error; SEE: Standard estimation error.