Retrospective Study
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World J Psychiatry. Mar 19, 2025; 15(3): 100120
Published online Mar 19, 2025. doi: 10.5498/wjp.v15.i3.100120
Repetitive transcranial magnetic stimulation guided by event-related potential P300 application in schizophrenia
Ai-Ming Gu, Chao Liang, Chao Liu, Ru-Ya Guo, Jin Hu, Xing-Shi Chen, Jun-Jie Xu, Jie Huang
Ai-Ming Gu, Jun-Jie Xu, Department of Neurology, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Chao Liang, Jie Huang, Department of General Practice, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Chao Liu, Department of Psychiatry, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Ru-Ya Guo, Department of Endocrinology, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Jin Hu, Department of Neurology, First Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Xing-Shi Chen, Department of Electrophysiology, Shanghai Mental Health Center, Shanghai 200030, China
Co-corresponding authors: Chao Liang and Chao Liu.
Author contributions: Gu AM, Hu J, and Chen XS designed the research; Gu AM, Liu C, Xu JJ, Guo RY, and Huang J performed the research; Liang C and Xu JJ contributed analytic tools; Gu AM and Liu C analyzed the data and wrote the manuscript; and all authors have read and approve the final manuscript. Liang C and Liu C contributed equally to this work as co-corresponding authors.
Supported by Key Discipline Construction Project of Neurology of Jiaxing City in Zhejiang Province of China, No. 2023-ZC-006.
Institutional review board statement: The study was reviewed and approved by the Shanghai Institute of Mental Health, No. 201505.
Informed consent statement: All research participants signed informed consent forms before the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Liang, MMed, Department of General Practice, The First Hospital of Jiaxing, No. 1882 Zhonghuan South Road, Jiaxing 314000, Zhejiang Province, China. liangchao202408@163.com
Received: October 23, 2024
Revised: December 2, 2024
Accepted: January 6, 2025
Published online: March 19, 2025
Processing time: 125 Days and 18.7 Hours
Core Tip

Core Tip: This study investigates the optimal frequency of repetitive transcranial magnetic stimulation (rTMS) in the treatment of schizophrenia and discovers that 10 Hz is superior to 5 Hz and 15 Hz. The innovations of this study consist of designing the experiment in accordance with the Chinese rTMS standard, utilizing the P300 to assess the treatment effect, formulating a detection plan and a quality assurance plan, and adjusting technical parameters. The results demonstrate that the Scale for Assessment of Negative Symptoms score improved in the 10 Hz group, and the P300 wave amplitude presented initial evidence of change. The conclusion is that 10 Hz is appropriate for adult schizophrenia patients, and P300 can serve as an electrophysiological evaluation indicator before and after rTMS treatment.