Selective serotonin reuptake inhibitors in the treatment of major depressive disorder after brain trauma: Systematic review and meta-analysis

Table 1 Study characteristics of 8 studies for major depressive disorder after traumatic brain injury

Ref.	Country	Antidepressant(s)	Weeks treated	n	SSRI (n)	Control (n)	Time since injury	Severity of injury	Outcome measure
Ansari et al[8], 2014	India	Sertraline	24	80	40	40	> 2 weeks	Mild and moderate	PHD-9
Ashman et al[13], 2009	United States	Sertraline	10	41	22	19	17 years	Mild to severe	HAM-D
Fann et al[14], 2000	United States	Sertraline	8	30	15	15	10.6 months	Mild	HAM-D
Fann et al[15], 2017	United States	Sertraline	12	53	24	29	4.6 months	Mild to severe	HAM-D
Jorge et al[11], 2016	Argentina	Sertraline	24	94	48	46	-	Severe	GCS
Lee et al[16], 2005	Korea	Methylphenidate and sertraline	4	30	20	10	32.2 days	Mild to moderate	HAM-D
Rao et al[17], 2016	United States	Escitalopram	12	14	8	6	Not reported	Not reported	MADRS
Rapoport et al[18], 2008	Canada	Citalopram	10	54	54	Self-control	< 1 year	Mild to severe	HAM-D

MDD: Major depressive disorder; TBI: Traumatic brain injury; SSRI: Selective serotonin reuptake inhibitor; PHD-9: 9-item Patient Health Questionnaire Depression Scale; HAM-D: Hamilton Depression Rating Scale; GCS: Glasgow Coma Scale; MADRS: Montreal Depression Rating Scale.