Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Mar 19, 2025; 15(3): 100103
Published online Mar 19, 2025. doi: 10.5498/wjp.v15.i3.100103
Selective serotonin reuptake inhibitors in the treatment of major depressive disorder after brain trauma: Systematic review and meta-analysis
Ren-Xian Gao, Xiao-Na Zhang, Peng Zhu
Ren-Xian Gao, Peng Zhu, Department of Emergency, Wenzhou People's Hospital (The Third Affiliated Hospital of Shanghai University), Wenzhou 325000, Zhejiang Province, China
Xiao-Na Zhang, Department of Orthopedics, Wenzhou Central Hospital, Wenzhou 325000, Zhejiang Province, China
Author contributions: Gao RX acquisition of data, analysis and interpretation of data, drafting the article, final approval; Zhang XN, Zhu P interpretation of data, revising the article, final approval.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng Zhu, Department of Emergency, Wenzhou People's Hospital (The Third Affiliated Hospital of Shanghai University), No. 299 Gu'an Road, Ouhai District, Wenzhou 325000, Zhejiang Province, China. 15868714401@163.com
Received: November 13, 2024
Revised: December 21, 2024
Accepted: January 22, 2025
Published online: March 19, 2025
Processing time: 104 Days and 20.9 Hours
Core Tip

Core Tip: Results of this meta-analysis indicate that selective serotonin reuptake inhibitors have advantages over placebos for the treatment of major depressive disorder after Traumatic brain injury. The incidence of adverse reactions after treatment did not differ substantially between the two groups. However, these studies did not exhibit heterogeneity, although the sample sizes of all studies included in this meta-analysis were relatively small (n < 100). This may have resulted in an overestimation of the treatment effects in small trials. Future prospective studies with larger sample sizes are needed to verify the results of the present study.