Analysis of risk factors for postoperative anxiety and depression in endometriosis patients with reproductive intention

Table 1 The occurrence and degree of anxiety and depression in patients with endometriosis

Symptom	Score	Asymptomatic	Symptomatic	Mild	Moderate	Severe
Anxiety	43.14 ± 8.44	260	61	56	4	1
Depressed	53.97 ± 10.94	101	220	132	85	3

Table 2 Demographic characteristics of endometriosis combined with anxiety or depression

Variable	Anxiety				Depression
	Yes	No	t/χ2	P value	Yes	No	t/χ2	P value
Age	31.74 ± 3.69	31.75 ± 4.41	0.01	0.989	31.80 ± 4.13	31.62 ± 4.60	-0.34	0.732
Smoking			5.57	0.018			6.12	0.013
Yes	10 (16.39)	18 (6.92)			25 (11.36)	3 (2.97)
No	51 (83.61)	242 (93.08)			195 (88.64)	98 (97.03)
Drinking			3.24	0.072			4.26	0.039
Yes	17 (27.87)	46 (17.69)			50 (22.73)	13 (12.87)
No	44 (72.13)	214 (82.31)			170 (77.27)	88 (87.13)
Coffee			5.00	0.025			0.26	0.611
Yes	22 (36.07)	58 (22.31)			53 (24.09)	27 (26.73)
No	39 (63.93)	202 (77.69)			167 (75.91)	74 (73.27)
Tea			0.17	0.681			1.20	0.274
Yes	9 (14.75)	44 (16.92)			34 (15.45)	11 (10.89)
No	52 (85.25)	216 (83.08)			186 (84.55)	90 (89.11)
Place of birth			0.79	0.672			1.49	0.476
City	15 (24.59)	77 (29.62)			61 (27.73)	31 (30.69)
Towns	14 (22.95)	50 (19.23)			41 (18.64)	23 (22.77)
Village	32 (52.46)	133 (51.15)			118 (53.64)	47 (46.53)
Place of Residence			2.58	0.275			2.80	0.246
City	49 (80.33)	186 (71.54)			167 (75.91)	68 (67.33)
Towns	8 (13.11)	39 (15.00)			28 (12.73)	19 (18.81)
Village	4 (6.56)	35 (13.46)			25 (11.36)	14 (13.86)
Spousal			0.19	0.662			4.63	0.031
Yes	57 (93.44)	249 (95.77)			214 (97.27)	92 (91.09)
No	4 (6.56)	11 (4.23)			6 (2.73)	9 (8.91)
Educational level			1.57	0.456			4.43	0.109
Junior high school and below	9 (14.75)	33 (12.69)			23 (10.45)	19 (18.81)
High school to junior college	18 (29.51)	99 (38.08)			81 (36.82)	36 (35.64)
Bachelor degree or above	34 (55.74)	128 (49.23)			116 (52.73)	46 (45.54)
Occupation			0.08	0.777			2.65	0.109
Permanent occupation	38 (62.30)	167 (64.23)			147 (66.82)	58 (57.43)
Freelance work	23 (37.70)	93 (35.77)			73 (33.18)	43 (42.57)
Annual household income			1.14	0.565			11.85	0.003
Low-income	22 (36.07)	89 (34.23)			70 (31.82)	41 (40.59)
Middle-income	19 (31.15)	99 (38.08)			74 (33.64)	44 (43.56)
High-income	20 (32.79)	72 (27.69)			76 (34.55)	16 (15.84)

Table 3 Clinical characteristics of endometriosis combined with anxiety or depression

Variable	Anxiety				Depression
	Yes	No	t/χ2	P value	Yes	No	t/χ2	P value
BMI	21.82 ± 3.24	21.80 ± 2.91	-0.05	0.960	21.76 ± 2.88	21.89 ± 3.17	0.35	0.725
History of blood transfusion			0.01	0.911			0.28	0.594
Yes	2 (3.28)	14 (4.36)			11 (5.00)	3 (2.97)
No	59 (96.72)	307 (95.64)			209 (95.00)	98 (97.03)
Knowing the age of EMS	28.15 ± 3.74	27.71 ± 4.28	-0.73	0.464	27.91 ± 4.04	27.54 ± 4.49	-0.73	0.469
EMS type			0.59	0.744			2.92	0.232
Peritoneal type	28 (45.90)	112 (43.08)			103 (46.82)	37 (36.63)
Ovarian type	21 (34.43)	103 (39.62)			80 (36.36)	44 (43.56)
Other types	12 (19.67)	45 (17.31)			37 (16.82)	20 (19.80)
EMS staging			8.47	0.037			78.06	< 0.001
Phase I	6 (9.84)	41 (15.77)			22 (10.00)	25 (24.75)
Phase II	5 (8.20)	54 (20.77)			17 (7.73)	42 (41.58)
Phase III	28 (45.90)	101 (38.85)			110 (50.00)	19 (18.81)
Phase IV	22 (36.07)	64 (24.62)			71 (32.27)	15 (14.85)
EMS medication			0.48	0.487			0.18	0.674
Yes	21 (34.43)	102 (39.23)			134 (60.91)	64 (63.37)
No	40 (65.57)	158 (60.77)			86 (39.09)	37 (36.63)
Chronic pelvic pain			7.22	0.007
Yes	19 (31.15)	42 (16.15)			40 (18.18)	21 (20.79)
No	42 (68.85)	218 (83.85)			180 (81.82)	80 (79.21)
Sexual discomfort			12.62	< 0.001			0.00	0.945
Yes	29 (39.34)	64 (24.62)			64 (29.09)	29 (28.71)
No	32 (52.46)	196 (75.38)			156 (70.91)	72 (71.29)
Infertility years	3.98 ± 3.14	3.57 ± 2.36	-1.12	0.264	3.65 ± 2.58	3.64 ± 2.43	-0.03	0.977
Age of menarche	13.54 ± 1.29	13.43 ± 1.28	-0.58	0.560	13.45 ± 1.21	13.47 ± 1.43	0.10	0.921
Menstrual cycle	30.90 ± 5.91	29.47 ± 4.93	-1.96	0.051	29.98 ± 5.74	29.23 ± 3.48	0.92	0.224
Menstrual period	6.47 ± 1.29	6.14 ± 1.23	-1.87	0.062	6.20 ± 1.22	6.23 ± 1.32	0.41	0.844
Dysmenorrhea			0.56	0.454			0.06	0.802
Yes	40 (65.57)	157 (60.38)			134 (60.91)	63 (62.38)
No	21 (34.43)	103 (39.62)			86 (39.09)	38 (37.62)
Childbearing history			1.46	0.226			1.13	0.288
Yes	11 (18.03)	66 (25.38)			49 (22.27)	28 (27.72)
No	50 (81.97)	194 (74.62)			171 (77.73)	73 (72.28)
History of abortion			0.88	0.349			0.47	0.491
Yes	12 (19.67)	66 (25.38)			51 (23.18)	27 (26.73)
No	49 (80.33)	194 (76.54)			169 (76.82)	74 (73.27)
SF-12 score	32.51 ± 2.84	32.70 ± 4.66	0.31	0.754	32.96 ± 3.25	32.02 ± 6.12	-1.80	0.073

BMI: Body mass index; EMS: Endometriosis; SF-12: Short Form-12 Health Survey.

Table 4 Univariate and multifactorial logistic analysis of anxiety in endometriosis patients

Variable	Univariate logistic analysis		Multivariate logistic analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Smoking
Yes	2.64 (1.15-6.05)	0.022	2.54 (1.06-6.11)	0.037
No	Reference		Reference
Coffee
Yes	1.96 (1.08-3.57)	0.027	1.92 (1.02-3.61)	0.042
No	Reference		Reference
Chronic pelvic pain
Yes	2.35 (1.24-4.43)	0.008	1.97 (1.01-3.85)	0.045
No	Reference		Reference
Sexual discomfort
Yes	2.78 (1.56-4.94)	< 0.001	2.60 (1.42-4.76)	0.002
No	Reference		Reference

Table 5 Univariate and multifactorial logistic analysis of depression in endometriosis patients

Variable	Univariate logistic analysis		Multivariate logistic analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Smoking
Yes	4.19 (1.23-14.21)	0.022	4.19 (1.10-15.93)	0.036
No	Reference		Reference
EMS staging
Phase I	Reference		Reference
Phase II	0.46 (0.21-1.03)	0.058	0.50 (0.21-1.16)	0.104
Phase III	6.58 (3.10-13.95)	< 0.001	7.67 (3.44-17.11)	< 0.001
Phase IV	5.38 (2.42-11.96)	< 0.001	6.12 (2.65-14.15)	< 0.001
Spousal
Yes	3.49 (1.21-10.09)	0.021	4.96 (1.48-16.63)	0.010
No	Reference		Reference
Annual household income
Low-income	0.36 (0.19-0.70)	0.002	0.40 (0.19-0.87)	0.020
Middle-income	0.35 (0.18-0.68)	0.002	0.42 (0.20-0.90)	0.025
High-income	Reference		Reference