Impact of comorbid subthreshold depressive symptoms on cancer-related fatigue and complications in adults with leukemia

doi:10.5498/wjp.v14.i7.1009

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Psychiatry. Jul 19, 2024; 14(7): 1009-1016
Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1009

Table 1 Comparison of basic clinical characteristics

	Subthreshold depression (n = 95)	Control (n = 100)	Statistic	P value
Age (years, mean ± SD)	65.3 ± 10.22	63.6 ± 12.4	0.585	0.561
Gender			χ² = 1.60	0.45
Male, n (%)	56 (58.94)	52 (52.00)
Female, n (%)	39 (41.05)	48 (48.00)
Marriage, n (%)			Fisher’s exact test	0.307
Married	63 (66.32)	50 (50.00)
Single	10 (10.52)	8 (8.00)
Bereft	10 (10.52)	12 (12.00)
Devoice	12 (12.65)	25 (25.00)
Work status, n (%)			χ² = 0.804	0.423
Unemployed	79 (0.84)	80 (80.00)
Employed	16 (0.17)	20 (20.00)
Comorbid chronic disease, n (%)			χ² = 0.795	0.428
Yes	12 (12.65)	10 (10.00)
No	83 (87.36)	90 (90.00)
BMI (kg/m², mean ± SD)	24.23 ± 9.29	23.91 ± 10.22	0.868	0.386
Combined radiotherapy, n (%)			χ² = 2.227	0.028
Yes	33 (35.76)	7 (7.00)
No	62 (65.26)	93 (93.00)
Regular exercise, n (%)			χ² = 2.609	0.010
Yes	12 (12.82)	54 (54.00)
No	83 (87.87)	46 (46.00)

Table 2 Comparison of observational indicators between the two groups

	Subthreshold depression (n = 95)	Control (n = 100)	Statistic	P value
Pain score (score, mean ± SD)	3.98 ± 2.43	1.34 ± 0.2	35.918	0.000
PSQI (score, mean ± SD)	11.0 ± 3.1	9.8 ± 1.8	1.841	0.070
Piper Fatigue Scale score (score, mean ± SD)	7.2 ± 1.6	4.5 ± 1.4	4.410	0.000
Hemoglobin (g/L, mean ± SD)	60.24 ± 12.45	71.19 ± 15.34	1.011	0.000
Albumin (g/L, mean ± SD)	33.98 ± 15.66	34.45 ± 19.46	1.534	0.128
CRP (mg/L, mean ± SD)	8.13 ± 1.55	4.24 ± 1.42	2.832	0.005

PSQI: Pittsburgh Sleep Quality Index; CRP: C-reactive protein.

Table 3 Correlation analysis of Piper Fatigue Scale scores in leukemia patients

	PFS score	Emotion	Recognition	Behavior	Sensation
Age	0.741^a	0.791^a	0.753^a	0.745^a	0.736^a
Pain	0.321	0.561	0.176	0.264	0.146
Hemoglobin	-0.667^a	-0.447	-0.453	-0.681^a	-0.636^a
CRP	0.463^a	0.328^a	0.285	0.339	0.642^a
Regular exercise	0.602^a	0.561^a	0.453	0.456	0.636^a

^aP < 0.05.

PFS: Piper Fatigue Scale; CRP: C-reactive protein.

Table 4 Multivariate regression analysis of piper fatigue scale scores in patients with malignant hematological diseases

	Value	B	SE	β	t value	P value
Age (years)		6.660	2.331	0.062	2.821	0.002^a
Concurrent radiotherapy	(No = 1, Yes = 2)	123.09	69.894	0.042	2.021	0.033^a
Regular exercise	(No = 1, Yes = 2)	-236.85	75.913	-0.068	-3.120	0.002^a
Pain	Score	2.014	0.421	0.102	4.420	< 0.001^a
Hemoglobin		2.825	1.333	0.043	2.081	0.031^a

^aP < 0.05.

Citation: Liu YX, Wang J. Impact of comorbid subthreshold depressive symptoms on cancer-related fatigue and complications in adults with leukemia. World J Psychiatry 2024; 14(7): 1009-1016
URL: https://www.wjgnet.com/2220-3206/full/v14/i7/1009.htm
DOI: https://dx.doi.org/10.5498/wjp.v14.i7.1009