Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2024; 14(7): 1009-1016
Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1009
Impact of comorbid subthreshold depressive symptoms on cancer-related fatigue and complications in adults with leukemia
Yue-Xian Liu, Juan Wang
Yue-Xian Liu, Juan Wang, Department of Hematology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, Shandong Province, China
Author contributions: Liu YX initiated the project, designed the experiment and conducted clinical data collection, and performed postoperative follow-up and recorded data; Wang J conducted a number of collation and statistical analysis, and wrote the original manuscript; both authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Central Hospital Affiliated to Shandong First Medical University.
Informed consent statement: This study obtained informed consent forms.
Conflict-of-interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan Wang, BMed, Department of Hematology, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Lixia District, Jinan 250013, Shandong Province, China. jifanzhenggu@126.com
Received: March 21, 2024
Revised: May 13, 2024
Accepted: June 18, 2024
Published online: July 19, 2024
Processing time: 112 Days and 18 Hours
Core Tip

Core Tip: In this randomized controlled trial, leukemia patients with subthreshold depression were compared with leukemia patients without subthreshold depression. Multiple regression analysis revealed that advanced age, combined radiotherapy, pain, and low hemoglobin were risk factors for cancer-related fatigue in leukemia patients with subthreshold depression, and regular exercise was a protective factor against cancer-related fatigue. The total incidence of leukemia complications in the control group (4%) was significantly lower than that in the depressive group (24.21%).