Wuling capsule combined with sertraline in the therapy of anxiety and depression with insomnia in adolescents

Table 1 Comparison of Hamilton Depression Scale between the two groups

HAMD score	Control group (n = 40)	Observation group (n = 40)	t value	P value
Before treatment	24.23 ± 2.02	24.40 ± 1.52	0.438	0.662
2 weeks after treatment	18.58 ± 2.39	16.78 ± 2.69	3.158	0.002
4 weeks after treatment	15.67 ± 4.02	12.85 ± 3.71	3.268	0.002
6 weeks after treatment	12.60 ± 2.38	9.05 ± 2.09	7.086	< 0.001
8 weeks after treatment	8.63 ± 1.05	6.65 ± 1.19	7.861	< 0.001

HAMD: Hamilton Depression Scale.

Table 2 Comparison of Hamilton Anxiety Scale between the two groups

HAMA score	Control group (n = 40)	Observation group (n = 40)	t value	P value
Before treatment	22.87 ± 2.43	23.12 ± 2.59	0.445	0.658
2 weeks after treatment	18.07 ± 3.12	15.53 ± 3.71	3.326	0.001
4 weeks after treatment	14.78 ± 3.72	12.03 ± 4.28	3.067	0.003
6 weeks after treatment	11.63 ± 2.52	8.35 ± 2.38	5.976	< 0.001
8 weeks after treatment	8.75 ± 1.26	5.68 ± 1.31	10.723	< 0.001

HAMA: Hamilton Anxiety Scale.

Table 3 Comparison of Insomnia severity index between the two groups

ISI score	Control group (n = 40)	Observation group (n = 40)	t value	P value
Before treatment	17.85 ± 2.74	17.78 ± 2.76	0.122	0.903
2 weeks after treatment	15.63 ± 3.65	12.63 ± 4.01	3.499	< 0.001
4 weeks after treatment	13.75 ± 2.42	10.83 ± 3.15	4.658	< 0.001
6 weeks after treatment	11.90 ± 2.31	7.58 ± 2.15	8.679	< 0.001
8 weeks after treatment	8.73 ± 1.11	5.63 ± 1.00	13.101	< 0.001

ISI: Insomnia severity index.

Table 4 Comparison of treatment effect between the two groups, n (%)

Index	Control group (n = 40)	Observation group (n = 40)	χ2	P value
Cure	15 (37.50)	27 (67.50)
Effective	14 (35.00)	11 (27.50)
Ineffective	11 (27.50)	2 (5.00)
Total effective rate	29 (72.50)	38 (95.00)	7.440	0.006