Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Dec 19, 2024; 14(12): 1860-1867
Published online Dec 19, 2024. doi: 10.5498/wjp.v14.i12.1860
Wuling capsule combined with sertraline in the therapy of anxiety and depression with insomnia in adolescents
Li-Li Duo, Gao-Feng Rao
Li-Li Duo, Department of Psychiatry, Taizhou Integrated Traditional Chinese and Western Medicine Hospital, Taizhou 317500, Zhejiang Province, China
Gao-Feng Rao, Department of Rehabilitation, Taizhou Integrated Traditional Chinese and West Medicine Hospital, Taizhou 317500, Zhejiang Province, China
Co-corresponding authors: Li-Li Duo and Gao-Feng Rao.
Author contributions: Duo LL and Rao GF contribute equally to this study as co-corresponding authors. Duo LL designs research; Duo LL conducts case collection; Rao GF guide the research.
Institutional review board statement: The study was reviewed and approved by the Taizhou Hospital of Integrated Chinese and Western Medicine Institutional Review Board.
Informed consent statement: All the participants or their legal guardians signed the informed consent form.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available. This study followed ethics review board regulations to ensure privacy rights and data confidentiality of all participants.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Li Duo, Department of Psychiatry, Taizhou Integrated Traditional Chinese and Western Medicine Hospital, Room 401, Building 6, Dongtai Shuyun Mingyuan, Taiping Street, Taizhou 317500, Zhejiang Province, China. duolili1128@163.com
Received: August 26, 2024
Revised: October 15, 2024
Accepted: November 11, 2024
Published online: December 19, 2024
Processing time: 93 Days and 2.6 Hours
Abstract
BACKGROUND

The treatment of adolescent patients with anxiety, depression and insomnia is challenging, and there is no ideal treatment method.

AIM

To evaluate the clinical efficacy of Wuling capsule combined with sertraline in the treatment of adolescent anxiety, depression and insomnia.

METHODS

Eighty adolescent patients with anxiety, depression with insomnia who were admitted to our hospital from April 1, 2022 to March 30, 2024. And the subjects were randomly classified into the control group (n = 40) and the observational group (n = 40). The control group was treated with a combination of sertraline and placebo. The observation group was treated with Wuling capsule in addition to sertraline. The two groups were cured continuously for 8 weeks. Insomnia severity index (ISI), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were used to evaluate the clinical symptoms before treatment and at 2, 4, 6 and 8 weeks after treatment. The Treatment Emergent Symptom Scale (TESS) was used to evaluate adverse reactions during treatment.

RESULTS

There was no obvious difference in HAMD, HAMA and ISI scores between the two groups before treatment (P > 0.05). After treatment, the HAMD, HAMA and ISI scores of patients in both groups decreased compared with before treatment, and HAMD, HAMA and ISI scores of patients in the observation group were remarkedly lower than those in the control group at each time point after treatment (P < 0.05). Compared with the control group, the TESS score of the study group were sharply lower (t = 18.239, P < 0.001).

CONCLUSION

Wuling capsule can further alleviate the insomnia symptoms of adolescents with anxiety and depression, and the efficacy and safety are high. It is recommended to promote the application.

Keywords: Adolescent; Depression; Anxiety; Insomnia symptom; Sertraline; Wuling capsules

Core Tip: This study discusses the clinical effect of Wuling capsule combined with Sertraline in the treatment of anxiety and depression with insomnia symptoms, and emphasizes that Wuling capsule can further alleviate the insomnia symptoms of anxiety and depression in adolescents, with high efficacy and safety. Therefore, this study proposed a combination treatment method, which can effectively improve the depression state and sleep quality of patients, and is conducive to improving the treatment compliance of patients, and it is recommended to be popularized.