Resting-state functional magnetic resonance imaging and support vector machines for the diagnosis of major depressive disorder in adolescents

Table 1 Demographic and clinical characteristics comparison of the two groups, mean ± SD

Demographic data	Patients (n = 44)	HCs (n = 43)	t value (orx²)	P value
Gender (male/female)	44 (10/34)	43 (10/33)	0.003	0.9531
Age (years)	15.02 ± 1.389	15.49 ± 1.831	-1.338	0.1842
Education (years)	9.43 ± 1.662	9.98 ± 2.006	-1.381	0.1712
HAMD score	27.09 ± 6.069	1.00 ± 1.746	27.114	< 0.0012

¹P for gender distribution was obtained by the χ² test.

²P were obtained by two sample I-tests.

HCs: Healthy controls; HAMD: Hamilton depression scale.

Table 2 Abnormal functional connectivity of brain regions in patients with major depressive disorder

Cluster location	Peak (MNI)			Cluster size (voxels)	t value
	X	Y	Z
Patients < HCs
Temporal_Inf_L	-45	3	-36	24	-6.08
Vermis_10	0	-45	-30	25	6.09
Calcarine_R	15	-93	-3	21	-5.19
Calcarine_L	-9	-78	3	38	-4.87
Lingual_R	24	-48	-3	21	-5.43
Occipital_Sup_L	-15	-84	21	41	-5.33

MNI: Montreal neurological institute.

Table 3 Results of the receiver operating characteristic analysis for functional connection values of different brain regions in distinguishing between the two groups

Brain regions	Accuracy	Sensitivity	Specificity
Temporal_Inf_L	68.97%	79.55%	58.14%
Vermis_10	70.11%	84.09%	55.81%
Calcarine_R	70.11%	61.36%	79.07%
Calcarine_L	66.67%	75.00%	58.14%
Lingual_R	83.91%	79.55%	88.37%
Occipital_Sup_L	65.52%	68.19%	62.79%