Factors influencing postoperative anxiety and depression following Iodine-131 treatment in patients with differentiated thyroid cancer: A cross-sectional study

Table 1 Characteristics of the survey population

Category	Variable	Number of samples	Percentage (%)
Age	< 30	66	45.83
	≥ 30	78	54.17
Sex	Male	70	48.61
	Female	74	51.39
Education	High school or above	68	47.22
	High school and below	76	52.78
Marital status	Have a spouse	69	47.92
	no spouse	75	52.08
Monthly household income	≥ 5000	70	48.61
	< 5000	74	51.39
Underlying medical conditions	Yes	71	49.31
	No	73	50.69
Medication adherence	Regular	67	46.53
	Irregular	77	53.47

Table 2 Overall status of anxiety and depression in patients undergoing ¹³¹I treatment after surgery for differentiated thyroid cancer

Category	Normal	Mild	Moderate	Severe
Anxiety	74 (51.39)	31 (21.52)	35 (24.30)	4 (2.78)
Depression	76 (52.78)	30 (20.83)	33 (22.92)	5 (3.47)

Table 3 Single factor analysis of anxiety in survey participants

Category		Anxiety (n = 70)	Non-anxiety (n = 74)	χ2	P value
Age	≤ 40	31 (44.29)	35 (47.30)	0.131	0.717
	> 40	39 (55.71)	39 (52.70)
Sex	Male	33 (47.14)	41 (55.40)	0.983	0.321
	Female	37 (52.86)	33 (44.59)
Education	High school or above	48 (68.57)	20 (27.03)	24.911	0.001
	High school and below	22 (31.43)	54 (72.97)
Marital status	Have a spouse	38 (54.29)	35 (47.30)	0.703	0.402
	No spouse	32 (45.71)	39 (52.70)
Monthly household income	≤ 5000	51 (72.86)	19 (25.68)	32.065	0.001
	> 5000	19 (27.14)	55 (74.32)
Underlying medical conditions	Yes	37 (52.86)	34 (45.95)	0.687	0.407
	No	33 (47.14)	40 (54.05)
Medication adherence	Irregular	56 (80.00)	11 (14.86)	61.342	0.001
	Regular	14 (20.00)	63 (85.14)

Table 4 Assignments

Category	Assignment
Age	≤ 40 = 1; > 40 = 0
Education	High school or above = 1; High school and below = 0
Sex	Male = 1; Female = 0
Marital status	Have a spouse = 1; No spouse = 0
Monthly household income	> 5000 = 1; ≤ 5000 = 0
Underlying medical conditions	Yes = 1; No = 0
Medication adherence	Regular = 1; Irregular = 0
Anxiety	Anxiety = 1; Non-anxiety = 0
Depression	Depression = 1; Non-depression = 0

Table 5 Multivariate logistic analysis of anxiety in differentiated thyroid cancer patients after ¹³¹I treatment and surgery

Factors	β	SE	Wald χ2 value	P value	OR	95%CI
Education	-1.256	0.518	5.872	0.015	0.285	0.103–0.786
Family monthly income	-2.402	0.587	16.719	0.001	0.091	0.029–0.286
Medication compliance	-3.292	0.585	31.617	0.001	0.037	0.012–0.117

SE: Standard error

Table 6 Univariate analysis of the depression in patients with differentiated thyroid cancer after ¹³¹I treatment and surgery

Catalog		Depression (n = 68)	Non-depression (n = 76)	χ2 value	P value
Age	≤ 40	34 (50.00)	32 (42.11)	0.901	0.343
	> 40	34 (50.00)	44 (57.89)
Sex	Male	27 (39.71)	47 (61.84)	7.040	0.008
	Female	41 (60.29)	29 (38.16)
Education	High school and below	34 (50.00)	34 (44.74)	0.399	0.528
	High school or above	34 (50.00)	42 (55.26)
Marital status	Have a spouse	22 (32.35)	51 (67.11)	17.341	0.001
	No spouse	46 (67.65)	25 (32.89)
Monthly household income	≤ 5000	37 (54.41)	33 (43.42)	1.735	0.188
	> 5000	31 (45.59)	43 (56.58)
Underlying medical conditions	Yes	44 (64.71)	27 (35.53)	7.614	0.006
	No	24 (35.29)	49 (64.47)
Medication adherence	Irregular	36 (52.94)	31 (40.79)	2.130	0.144
	Regular	32 (47.06)	45 (59.21)

Table 7 Multivariate Logistic analysis of depression in differentiated thyroid cancer patients after ¹³¹I treatment and surgery

Factors	β	SE	Wald χ2 value	P value	OR	95%CI
Sex	-1.096	0.405	7.323	0.007	0.334	0.151–0.739
Marital status	-1.616	0.401	16.210	0.001	0.199	0.091–0.436
Underlying diseases	-1.027	0.396	6.737	0.009	0.358	0.165–1.038

SE: Standard error; OR: Odds ratio.