Identification and characterization of noncoding RNAs-associated competing endogenous RNA networks in major depressive disorder

Table 1 The twenty differentially expressed long noncoding RNAs and differentially expressed_microRNA pairs identified in this study

lncRNA	miRNA
STAG3L4	hsa-miR-4465
MTERFD2	hsa-miR-4465
TCL6	hsa-miR-4465
MDS2	hsa-miR-4465
LINC00202	hsa-miR-4465
LINC00402	hsa-miR-4465
TCL6	hsa-miR-137
ANKRD36BP2	hsa-miR-137
LINC00202	hsa-miR-137
LINC00402	hsa-miR-137
MIR600HG	hsa-miR-137
MTERFD2	hsa-miR-125b-5p
HCG4	hsa-miR-125b-5p
TCL6	hsa-miR-125b-5p
UBE2Q2P2	hsa-miR-125b-5p
TREML2P1	hsa-miR-125b-5p
KIAA0125	hsa-miR-125b-5p
ANKRD36BP2	hsa-miR-125b-5p
LINC00202	hsa-miR-125b-5p
MIR600HG	hsa-miR-125b-5p

lncRNA: Long noncoding RNA; miRNA: microRNA.

Table 2 The forty-three differentially expressed_mRNAs and differentially expressed microRNA pairs identified in this study

miRNA	mRNA
hsa-miR-4465	FAM98B
hsa-miR-4465	ADM
hsa-miR-4465	INHBB
hsa-miR-4465	FA2H
hsa-miR-4465	HOXA9
hsa-miR-4465	GRB10
hsa-miR-4465	UGT8
hsa-miR-4465	ACVR1C
hsa-miR-4465	COL19A1
hsa-miR-4465	TTC28
hsa-miR-4465	HAS3
hsa-miR-4465	SLC22A23
hsa-miR-4465	ADAM23
hsa-miR-4465	NACC2
hsa-miR-4465	SH3PXD2A
hsa-miR-4465	CELSR1
hsa-miR-4465	PLEKHG1
hsa-miR-4465	ZSWIM5
hsa-miR-137	AKAP2
hsa-miR-137	HLF
hsa-miR-137	FGF9
hsa-miR-137	GLIS2
hsa-miR-137	SIPA1L2
hsa-miR-137	WNT7A
hsa-miR-137	NRG1
hsa-miR-137	ADAM23
hsa-miR-137	LRRC4
hsa-miR-137	SLC22A23
hsa-miR-137	COL19A1
hsa-miR-137	TTC28
hsa-miR-137	APLN
hsa-miR-137	NACC2
hsa-miR-137	BACH2
hsa-miR-137	ACVR1C
hsa-miR-125b-5p	NIPAL4
hsa-miR-125b-5p	NR6A1
hsa-miR-125b-5p	ZSWIM5
hsa-miR-125b-5p	GALNT14
hsa-miR-125b-5p	GRB10
hsa-miR-125b-5p	ELOVL4
hsa-miR-125b-5p	ACVR1C
hsa-miR-125b-5p	RALGPS2
hsa-miR-125b-5p	GLIS2

FA2H: Fatty acid 2-hydroxylase.

Table 3 The significant Gene Ontology terms identified in this study

Category	Term description	Count of genes	P value
Biology process	Activin receptor signaling pathway	3	5.54E-05
Biology process	Peripheral nervous system development	3	0.000292
Biology process	G protein-coupled receptor internalization	2	0.0003
Biology process	Desensitization of G protein-coupled receptor signaling pathway	2	0.000487
Biology process	Negative adaptation of signaling pathway	2	0.000487
Biology process	Positive regulation of vascular endothelial growth factor receptor signaling pathway	2	0.000487
Biology process	Adaptation of signaling pathway	2	0.000597
Biology process	Uterus development	2	0.000656
Biology process	Sphingolipid biosynthetic process	3	0.000679
Biology process	Reproductive structure development	5	0.00078
Cellular component	Glutamatergic synapse	4	0.002395
Cellular component	Schaffer collateral-CA1 synapse	2	0.00786
Cellular component	Cul2-RING ubiquitin ligase complex	1	0.024149
Cellular component	Integral component of synaptic membrane	2	0.025933
Cellular component	Intrinsic component of synaptic membrane	2	0.029786
Cellular component	Extracellular matrix	3	0.044750
Cellular component	Podosome	1	0.047732
Cellular component	Excitatory synapse	1	0.075303
Cellular component	Integral component of postsynaptic density membrane	1	0.079823
Cellular component	Intrinsic component of postsynaptic density membrane	1	0.084321
Molecular function	Receptor ligand activity	6	0.000191
Molecular function	Hormone activity	3	0.001352
Molecular function	UDP-glycosyltransferase activity	3	0.002314
Molecular function	Guanyl-nucleotide exchange factor activity	4	0.002772
Molecular function	Growth factor activity	3	0.003326
Molecular function	Transferase activity, transferring hexosyl groups	3	0.006074
Molecular function	Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	2	0.006746
Molecular function	Cytokine activity	3	0.007189
Molecular function	Phosphatidylinositol bisphosphate kinase activity	2	0.007334
Molecular function	Transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	4	0.008356