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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Feb 19, 2023; 13(2): 36-49
Published online Feb 19, 2023. doi: 10.5498/wjp.v13.i2.36
Published online Feb 19, 2023. doi: 10.5498/wjp.v13.i2.36
Identification and characterization of noncoding RNAs-associated competing endogenous RNA networks in major depressive disorder
Zhi-Li Zou, Bo Zhou, Department of Psychosomatic, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Yu Ye, Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 611130, Sichuan Province, China
Yuan Zhang, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Author contributions: Zou ZL contributed to study design, manuscript preparation, inspection, and revision; Ye Y contributed to manuscript preparation; Bo Z contributed to study design; Zhang Y contributed to study design and manuscript preparation.
Supported by the National Key Research and Development Program of China , No. 2020YFC2005500 .
Institutional review board statement: This study involves no human or animal subjects.
Conflict-of-interest statement: The authors report no conflict of interest.
Data sharing statement: The datasets using in this study were from NCBI GEO public databases.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan Zhang, MS, Assistant Professor, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, No. 32 First Ring Road West 2, Chengdu 610072, Sichuan Province, China. 447415054@qq.com
Received: October 9, 2022
Peer-review started: October 9, 2022
First decision: November 27, 2022
Revised: December 6, 2022
Accepted: January 23, 2023
Article in press: January 23, 2023
Published online: February 19, 2023
Processing time: 130 Days and 21.4 Hours
Peer-review started: October 9, 2022
First decision: November 27, 2022
Revised: December 6, 2022
Accepted: January 23, 2023
Article in press: January 23, 2023
Published online: February 19, 2023
Processing time: 130 Days and 21.4 Hours
Core Tip
Core Tip: Competing endogenous RNAs (ceRNAs) are novel regulatory molecules involved in a wide range of biological processes and diseases. This study explored the potential ceRNA networks (ceRNETs) involved in the pathogenesis of major depressive disorder (MDD) using bioinformatics data mining. A ceRNET comprising 3 miRNAs, 12 lncRNAs, and 33 mRNAs was constructed based on two public datasets obtained from the Gene Expression Omnibus database. Elucidating the correlation of the ceRNET with MDD opens new avenues to discover specific diagnostic biomarkers for MDD and expands our knowledge about this disease.