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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Comorbidity of bipolar and anxiety disorders: An overview of trends in research
Mamidipalli Sai Spoorthy, Subho Chakrabarti, Sandeep Grover, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Author contributions: All authors equally contributed to this paper with conception and design of the literature review and analysis, drafting, critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Subho Chakrabarti, MD, Professor, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. subhochd@yahoo.com
Telephone: +91-172-2756808 Fax: +91-172-2744401
Received: September 30, 2018
Peer-review started: September 30, 2018
First decision: October 17, 2018
Revised: November 4, 2018
Accepted: December 5, 2018
Article in press: December 5, 2018
Published online: January 4, 2019
Peer-review started: September 30, 2018
First decision: October 17, 2018
Revised: November 4, 2018
Accepted: December 5, 2018
Article in press: December 5, 2018
Published online: January 4, 2019
Core Tip
Core tip: This review of existing research shows that about half of those with bipolar disorder (BD) are likely to develop anxiety disorders in their lifetimes and a third of them will manifest these disorders at any point of time. Anxiety disorder comorbidity negatively impacts almost all aspects of the presentation and course of BD and makes for a much poorer treatment-response and outcome. Though research data on aetiology and management of such comorbidity is limited, clinicians need to screen patients with BD for anxiety disorders and provide comprehensive and on-going treatment to prevent the deleterious consequences of anxiety disorder comorbidity in BD.