Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Mar 22, 2016; 6(1): 102-117
Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.102
Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.102
Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics
Chi-Yu Lai, Elizabeth Scarr, Madhara Udawela, Ian Everall, Brian Dean, the Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3010, Australia
Chi-Yu Lai, Wei J Chen, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan
Chi-Yu Lai, Wei J Chen, Center of Genomic Medicine, National Taiwan University, Taipei 100, Taiwan
Elizabeth Scarr, Ian Everall, Brian Dean, Department of Psychiatry, the University of Melbourne, Parkville, VIC 3010, Australia
Author contributions: Lai CY and Scarr E wrote the paper; Lai CY summarized the review table; Scarr E, Udawela M, Everall I, Chen WJ and Dean B made critical revision in the manuscript; Lai CY and Dean B composed the structures the article; Dean B contributed to the idea of the review.
Supported by The National Science Council of Taiwan, Nos. 102-2917-I-002-002 and 103-2811-B-002-107; the Australian Research Council, No. FT100100689; and the National Health and Medical Research Council, No. APP1002240.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chi-Yu Lai, PhD, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 17 Xu-Zhou Road, Taipei 100, Taiwan. jchiyulai@gmail.com
Telephone: +886-2-33668010 Fax: +886-2-33668004
Received: August 11, 2015
Peer-review started: August 17, 2015
First decision: September 28, 2015
Revised: October 20, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: March 22, 2016
Peer-review started: August 17, 2015
First decision: September 28, 2015
Revised: October 20, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: March 22, 2016
Core Tip
Core tip: In recent years, there has been search for blood-based biomarkers for schizophrenia (Sz) as a valid alternative. However, it must be acknowledged that Sz is a complex and heterogeneous disorder which needs to be further dissected into subtype using biomarkers. The scope of this review is to critically examine published blood-based biomarker of Sz, focusing on possible uses for diagnosis, treatment response, and their relationship with schizophrenia-associated phenotype. We suggest that a prediction model-based, Sz specific, blood oriented study design as well as standard blood collection procedures would be useful for development of Sz biomarkers.