Cai ZY, Chen C, Huang ZY, Ye XW, Jin XZ, Chen HR, Sha JM. Cerebral hemodynamic characteristics of patients with auditory verbal hallucinations and the construction of nomogram models. World J Psychiatry 2025; 15(6): 106775 [DOI: 10.5498/wjp.v15.i6.106775]
Corresponding Author of This Article
Jian-Min Sha, Associate Professor, Department of Affective Disorders Ward of the Psychiatry, Wenzhou Seventh People’s Hospital, No. 158 Xueshiqian Village, Ouhai District, Wenzhou 325000, Zhejiang Province, China. shajm163@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Jun 19, 2025; 15(6): 106775 Published online Jun 19, 2025. doi: 10.5498/wjp.v15.i6.106775
Cerebral hemodynamic characteristics of patients with auditory verbal hallucinations and the construction of nomogram models
Zi-Yao Cai, Ce Chen, Zi-Ye Huang, Xin-Wu Ye, Xiao-Zhuang Jin, Hao-Ran Chen, Jian-Min Sha
Zi-Yao Cai, Department of Traditional Chinese Medicine Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
Ce Chen, Zi-Ye Huang, Xiao-Zhuang Jin, Hao-Ran Chen, Department of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
Xin-Wu Ye, Department of Geriatric Psychiatry Ward of the Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
Jian-Min Sha, Department of Affective Disorders Ward of the Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
Author contributions: Cai ZY wrote the paper and performed the research; Chen C, Huang ZY, and Ye XW contributed analytic tools; Jin XZ and Chen HR analyzed the data; Sha JM designed the research; all authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Wenzhou Seventh People’s Hospital, approval No. EC-20200610-02.
Informed consent statement: All subjects agreed to the study protocol.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Min Sha, Associate Professor, Department of Affective Disorders Ward of the Psychiatry, Wenzhou Seventh People’s Hospital, No. 158 Xueshiqian Village, Ouhai District, Wenzhou 325000, Zhejiang Province, China. shajm163@163.com
Received: March 12, 2025 Revised: April 7, 2025 Accepted: May 6, 2025 Published online: June 19, 2025 Processing time: 78 Days and 1.7 Hours
Core Tip
Core Tip: This study explores cerebral hemodynamic characteristics in patients with auditory verbal hallucinations (AVHs) across schizophrenia, post-traumatic stress disorder, and recurrent depressive disorder. Key findings include increased mean velocity-anterior cerebral artery and end-diastolic velocity-vertebral artery as independent risk factors for AVHs in schizophrenia, while decreased end-diastolic velocity-resistance index (middle cerebral artery) and mean velocity-vertebral artery serve as protective factors. Nomogram models were developed to predict the risks of AVHs, demonstrating high discriminative ability with an area under the curve greater than 0.80 and significant clinical utility, thereby supporting early diagnosis and intervention strategies.
