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World J Psychiatry. Feb 19, 2025; 15(2): 100214
Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.100214
Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.100214
Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferation via the CaMKII-CREB-BDNF pathway in schizophrenia
Feng Li, Xing Ren, Jia-Xiu Liu, Xiao-Bin Wei, Department of Clinical Laboratory, The Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, Hainan Province, China
Feng Li, Department of Clinical Laboratory, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, Hainan Province, China
Xing Ren, Blood Testing Center, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China
Tian-Dao Wang, Department of Clinical Laboratory, Hainan Provincial Anning Hospital, Haikou 570206, Hainan Province, China
Bi Wang, Department of Clinical Laboratory, Hainan Fifth People's Hospital (Hainan Skin Disease and Plastic Surgery Hospital), Haikou 570206, Hainan Province, China
Co-first authors: Feng Li and Xing Ren.
Co-corresponding authors: Bi Wang and Xiao-Bin Wei.
Author contributions: Li F, Reng X, Liu JX and Wang B performed experimental work and data analysis; Wang TD prepared figures and/or tables; Li F and Ren X written the first draft of the manuscript; All authors commented on previous versions of the manuscript. Both Wei XB and Wang B have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. Wei XB applied for and obtained the funds for this research project. Wei XB conceptualized, designed, and supervised the whole process of the project. Wang B was instrumental and responsible for data re-analysis and re-interpretation, as well as revision and preparation of the current version of the manuscript.
Supported by the Key R&D Projects of Hainan Province, No. ZDYF2022SHFZ295.
Institutional review board statement: The study was reviewed and approved by Biomedical Ethics Committee of Haikou People's Hospital, Approval No. 2021- (Ethics Review)-263. Additionally, it was approved by the Biomedical Ethics Committee of Hainan Anning Hospital, Approval No. 2022- (Ethics Review)-2.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data are available from the corresponding author on reasonable request at weixb1972@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Bin Wei, MD, Professor, Department of Clinical Laboratory, The Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No. 43 Renmin Avenue, Meilan District, Haikou 570208, Hainan Province, China.
Received: August 10, 2024
Revised: November 26, 2024
Accepted: December 17, 2024
Published online: February 19, 2025
Processing time: 157 Days and 7 Hours
Revised: November 26, 2024
Accepted: December 17, 2024
Published online: February 19, 2025
Processing time: 157 Days and 7 Hours
Core Tip
Core Tip: The strength of this study lies in the integration of transcriptomics and proteomics data from the same sample source (peripheral blood mononuclear cells) to better observe mRNA-protein inconsistencies and mRNA-protein correlations, thus explaining the biology of schizophrenia in a holistic manner. Proteomics and transcriptomics correlation analyses provide a panoramic view of the expression profile of schizophrenia, enabling complementarity and integration at the transcriptional and protein levels. Again, this study is one of the few to investigate the role of the SERPING1 gene in neural cell proliferation and apoptosis.