Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Aug 19, 2024; 14(8): 1216-1223
Published online Aug 19, 2024. doi: 10.5498/wjp.v14.i8.1216
Alzheimer's disease with depressive symptoms: Clinical effect of intermittent theta burst stimulation repetitive transcranial magnetic stimulation
Xin Jin, Chun-Yun Xu, Jin-Feng Fei, Yu Fang, Cong-Hao Sun
Xin Jin, Chun-Yun Xu, Jin-Feng Fei, Yu Fang, Cong-Hao Sun, Department of Psychiatry, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou 313000, Zhejiang Province, China
Author contributions: Jin X designed and conducted the research; Sun CH designed and supervised the research; Xu CY, Fei JF, and Fang Y collected and analyzed the data; All authors approved the manuscript.
Supported by Huzhou Science and Technology Plan Project, No. 2019GZ38.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Boards of Huzhou Third Municipal Hospital and the Affiliated Hospital of Huzhou University.
Informed consent statement: All study participants or their legal guardians provided written informed consent for personal and medical data collection before study enrolment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: This dataset is available from the corresponding author. Participants provided informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cong-Hao Sun, MBBS, Attending Doctor, Department of Psychiatry, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, No. 2088 Tiaoxi Dong Road, Huzhou 313000, Zhejiang Province, China. horensu@163.com
Received: June 17, 2024
Revised: July 15, 2024
Accepted: July 17, 2024
Published online: August 19, 2024
Processing time: 55 Days and 20.6 Hours
Core Tip

Core Tip: Alzheimer's disease (AD) predominantly impacts brain neurons, being a chronic neurodegenerative condition. With disease progression, many patients with AD experience depressive symptoms, significantly impeding their lives while imposing a substantial strain on families and society. Therefore, this study investigated the clinical effects of repetitive transcranial magnetic stimulation-intermittent theta burst stimulation (iTBS-rTMS) on patients with AD experiencing depressive symptoms. Our findings suggest iTBS-rTMS significantly improves depressive symptoms and shows promise in enhancing cognitive function, offering a novel approach to managing comorbid depression in patients with AD and promoting the development of the field of neuroscience.