Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2024; 14(7): 1106-1117
Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1106
Multimodal abnormalities of brain structures in adolescents and young adults with major depressive disorder: An activation likelihood estimation meta-analysis
Yan-Ping Shu, Qin Zhang, Yong-Zhe Hou, Shuang Liang, Zu-Li Zheng, Jia-Lin Li, Gang Wu
Yan-Ping Shu, Yong-Zhe Hou, Zu-Li Zheng, Gang Wu, Department of Psychiatry of Women and Children, The Second People’s Hospital of Guizhou Province, Guiyang 550000, Guizhou Province, China
Qin Zhang, Shuang Liang, Department of Radiology, The Second People’s Hospital of Guizhou Province, Guiyang 550000, Guizhou Province, China
Qin Zhang, Department of Radiology, Guizhou Provincial People’s Hospital, Guiyang 550000, Guizhou Province, China
Jia-Lin Li, Medical Humanities College, Guizhou Medical University, Guiyang 550000, Guizhou Province, China
Co-corresponding authors: Yong-Zhe Hou and Gang Wu.
Author contributions: Shu YP conceptualized and designed the research framework; Hou YZ and Zhang Q were responsible for conducting the literature search, carrying out the initial screening, extracting relevant data, and performing the analytical computations; Liang S, Zheng ZL, Li JL, and Wu G contributed to critical revisions that significantly improved the intellectual content of the manuscript. Wu G and Hou YZ contributed equally to this manuscript and are therefore listed as co-corresponding authors. This designation as co-corresponding authors underscores our shared responsibilities in handling correspondence, communicating with peers, and providing essential guidance throughout the research process.
Supported by the Guizhou Province Science and Technology Plan Project, No. ZK-2023-195; and 2021 Health Commission of Guizhou Province Project, No. gzwkj2021-150.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Wu, PhD, Professor, Department of Psychiatry of Women and Children, The Second People’s Hospital of Guizhou Province, No. 206 South Section of Xintian Avenue, Guiyang 550000, Guizhou Province, China. 738446124@qq.com
Received: March 30, 2024
Revised: May 10, 2024
Accepted: May 27, 2024
Published online: July 19, 2024
Processing time: 104 Days and 0.8 Hours
Core Tip

Core Tip: This activation likelihood estimation (ALE) meta-analysis illuminates significant structural brain changes in adolescents and young adults with major depressive disorder (MDD), particularly in the right caudate head, right insula, and right lentiform nucleus putamen, highlighting their potential as neural markers. By employing ALE across diffusion tensor imaging and voxel-based morphometry studies, the research reveals consistent patterns of reduced fractional anisotropy, underscoring the recurrent nature of MDD. These insights provide a deeper understanding of its neuropathology and highlights the critical role of specialized neuroimaging in unraveling the complex mechanisms underlying MDD.