Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Mar 19, 2024; 14(3): 370-379
Published online Mar 19, 2024. doi: 10.5498/wjp.v14.i3.370
Brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients
Hong-Xun Yuan, Li-Na Zhang, Gang Li, Li Qiao
Hong-Xun Yuan, Gang Li, Li Qiao, Intensive Care Unit, Peking University International Hospital, Beijing 102206, China
Li-Na Zhang, Central Operating Room, The Affiliated Beijing Chaoyang Hospital of Capital Medical University, Beijing 100020, China
Co-first authors: Hong-Xun Yuan and Li-Na Zhang.
Co-corresponding authors: Gang Li and Li Qiao.
Author contributions: Yuan HX and Zhang LN contributed to conception, writing, and statistical analysis; Li G and Qiao L contributed to project, manuscript writing, review, and revision; all authors were involved in the critical review of the results and have contributed to, read, and approved the final manuscript. Yuan HX and Zhang LN contributed equally to this work as co-first authors; Li G and Qiao L contributed equally to this work as co-corresponding authors. The reasons for designating Gang Li and Li Qiao as co-corresponding authors are listed below: The research was performed as a collaborative effort, and the designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper’s quality and reliability. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. In summary, we believe that designating Li G and Qiao L as co-corresponding authors of is fitting for our manuscript as it accurately reflects our team’s collaborative spirit, equal contributions, and diversity.
Institutional review board statement: This study has been reviewed and approved by the Ethics Committee of Peking University International Hospital (Approval No. 2021-KY-0037-01).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at ligang1@pkuih.edu.cn.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Li, BSc, Consultant, Intensive Care Unit, Peking University International Hospital, No. 1 Life Park Road, Zhongguancun Life Science Park, Changping District, Beijing 102206, China. ligang1@pkuih.edu.cn
Received: October 18, 2023
Peer-review started: October 18, 2023
First decision: December 6, 2023
Revised: December 21, 2023
Accepted: January 15, 2024
Article in press: January 15, 2024
Published online: March 19, 2024
Processing time: 153 Days and 1.1 Hours
Core Tip

Core Tip: In this study, we designed a single center, prospective, randomized controlled study to compare the brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients.