Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2024; 14(11): 1652-1660
Published online Nov 19, 2024. doi: 10.5498/wjp.v14.i11.1652
Application of proton magnetic resonance spectroscopy in metabolic alterations of prefrontal white and gray matter in depression adolescents
Ying Zou, Yu-Qin Wu, Yao-Jing Han, Xiao-Ming He, Jiang Zhao
Ying Zou, Yao-Jing Han, Department of Clinical Psychology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Yu-Qin Wu, Xiao-Ming He, Department of Endocrine and Metabolic Diseases, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Jiang Zhao, Department of Radiology, Hangzhou Cancer Hospital, Hangzhou 310002, Zhejiang Province, China
Author contributions: Zou Y wrote the manuscript; Zhao J reviewed the manuscript; Zou Y, Wu YQ, Han YJ, He XM and Zhao J collected the data; all authors annotated the manuscript.
Supported by the General Scientific Research Project of Zhejiang Provincial Department of Education, No. Y202248840 and No. Y201942374.
Institutional review board statement: This study was approved by the Ethic Committee of The Second Affiliated Hospital of Zhejiang Chinese Medical University (Approval No. 2024 Research No. 035-01).
Informed consent statement: The Institutional Review Board waived the requirement for informed consent.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang Zhao, BMed, Doctor, Department of Radiology, Hangzhou Cancer Hospital, No. 34 Yanguan Lane, Zhongshan South Road, Shangcheng District, Hangzhou 310002, Zhejiang Province, China. hzzhaojiang@163.com
Received: July 10, 2024
Revised: July 30, 2024
Accepted: August 1, 2024
Published online: November 19, 2024
Processing time: 119 Days and 21.1 Hours
Core Tip

Core Tip: The prefrontal cortex and anterior cingulate gyrus are the key regions that play a significant role in emotional processing and modulation, and the thalamus is closely related to emotional activities. In this study, multi-voxel proton magnetic resonance spectroscopy scans were performed on the frontal white matter, anterior cingulate gray matter, and thalami in adolescents with depression, to explore the biochemical basis of the pathogenesis of teen depression.