Zhan ZH, Wang JL, Wang LH, Shen NN, Liu XW, Yu YN, Liu FR. Mechanism of imipenem-induced mental disorder: A meta-analysis. World J Psychiatry 2024; 14(10): 1583-1591 [DOI: 10.5498/wjp.v14.i10.1583]
Corresponding Author of This Article
Zhou-Hong Zhan, BSc, Department of Clinical Pharmacy, Affiliated Hospital of Shaoxing University, No. 999 Zhongxing South Road, Shaoxing 312000, Zhejiang Province, China. 15957500132@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhou-Hong Zhan, Jia-Liang Wang, Li-Hong Wang, Nan-Nan Shen, Xin-Wen Liu, Yan-Na Yu, Fu-Rong Liu, Department of Clinical Pharmacy, Affiliated Hospital of Shaoxing University, Shaoxing 312000, Zhejiang Province, China
Author contributions: Zhan ZH designed and performed research; Wang JL, Wang LH and Liu FR contributed new reagents or analytic tools; Shen NN and Yu YN analyzed data; Liu XW and Liu FR wrote the paper.
Supported bythe Education Research Program Project of Zhejiang Province, No. Y202043224.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhou-Hong Zhan, BSc, Department of Clinical Pharmacy, Affiliated Hospital of Shaoxing University, No. 999 Zhongxing South Road, Shaoxing 312000, Zhejiang Province, China. 15957500132@163.com
Received: August 6, 2024 Revised: September 3, 2024 Accepted: September 20, 2024 Published online: October 19, 2024 Processing time: 72 Days and 0.2 Hours
Core Tip
Core Tip: Imipenem is widely used in clinical treatments because of its high efficiency, enzyme resistance, and broad-spectrum antibacterial properties. However, reports of its adverse reactions are increasing daily, among which nervous system adverse reactions are the most common, usually showing symptoms similar to those of nervous system diseases, mental disorders, and aggravating the original nervous system diseases. It has been reported that imipenem can cause insomnia, intermittent delirium and unconsciousness, and its nervous system adverse reactions are related to age, renal insufficiency, hypoxemia, and dosage. Although the adverse effects of imipenem on the nervous system have been recognized in reports both at home and abroad, there is still a lack of in-depth and systematic research on its specific mechanism of causing mental disorders. Owing to the differences in the intervention measures and evaluation methods of different studies, the effectiveness and comprehensiveness of existing research results are limited to some extent. Therefore, this study collected and analyzed relevant literature at home and abroad on imipenem-induced mental disorders and deeply explored its potential mechanism, providing a scientific and comprehensive reference for patients to use drugs safely.
