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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2024; 14(10): 1484-1494
Published online Oct 19, 2024. doi: 10.5498/wjp.v14.i10.1484
Published online Oct 19, 2024. doi: 10.5498/wjp.v14.i10.1484
Interoception mediates the association between social support and sociability in patients with major depressive disorder
Wen-Liang Wang, Xiao-Hong Liu, Yu-Hang Ma, Li-Min Chen, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi 214151, Jiangsu Province, China
Ji-Kang Liu, Yi-Fan Sun, Xue-Zheng Gao, Zhen-He Zhou, Department of Psychiatry, The Affiliated Mental Health Center of Nanjing Medical University, Wuxi 214151, Jiangsu Province, China
Hong-Liang Zhou, Department of Psychology, The Affiliated Hospital of Jiangnan University, Wuxi 214151, Jiangsu Province, China
Co-first authors: Wen-Liang Wang and Ji-Kang Liu.
Co-corresponding authors: Zhen-He Zhou and Hong-Liang Zhou.
Author contributions: Zhou ZH and Zhou HL designed the study; Wang WL analyzed the data, and wrote the manuscript; Liu JK and Ma YH collected the relevant data; Zhou ZH provided financial support; Gao XZ, Sun YF, Liu XH, and Chen LM provided technological support; Zhou ZH and Zhou HL edited the manuscript; and all authors have read and approved the final manuscript.
Supported by the Wuxi Municipal Health Commission Major Project , No. 202107 .
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the affiliated mental health center of Jiangnan University, No. WXMHCIRB2022LLky010.
Informed consent statement: All participants enrolled into this study provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Data used in this study can be available from the corresponding author at zhouzh@njmu.edu.cn.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-He Zhou, MD, PhD, President, Professor, Department of Psychiatry, The Affiliated Mental Health Center of Nanjing Medical University, No. 156 Qianrong Road, Wuxi 214151, Jiangsu Province, China. zhouzh@nimu.edu.cn
Received: July 4, 2024
Revised: August 20, 2024
Accepted: September 2, 2024
Published online: October 19, 2024
Processing time: 105 Days and 7.9 Hours
Revised: August 20, 2024
Accepted: September 2, 2024
Published online: October 19, 2024
Processing time: 105 Days and 7.9 Hours
Core Tip
Core Tip: Interoception dysfunction is closely related to the development of major depression. Social support and sociability have a vital impact on depressed patients. Our study investigated the mediating effect of interoception between social support and social ability, explored the independent role of social support in sociability, and concluded that interoceptive awareness is a mediating factor between social support and sociability in both healthy controls and depressed patients. The mediating effect was lower in depressed patients than in healthy controls, which may be one of the reasons why patients with depression have reduced social skills.