Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Oct 19, 2024; 14(10): 1429-1436
Published online Oct 19, 2024. doi: 10.5498/wjp.v14.i10.1429
Bidirectional relationship between diabetes mellitus and depression: Mechanisms and epidemiology
Yun Liu, Shi-Yan Huang, De-Le Liu, Xin-Xing Zeng, Xiao-Rui Pan, Jie Peng
Yun Liu, Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Number 43, Shangfang Road, Nanchang 330029, China
Shi-Yan Huang, Xin-Xing Zeng, Xiao-Rui Pan, Jie Peng, The Second Clinical Medical College, Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
De-Le Liu, Department of Psychosomatic Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi Province, China
Co-corresponding authors: Yun Liu and Jie Peng.
Author contributions: Peng J and Liu Y designed and implemented the content of this manuscript, and are the co-corresponding author of this article; Liu Y, Huang SY wrote the manuscript; Liu DL, Zeng XX, Pan XR contributed to this paper; Peng J revised and reviewed the manuscript. All authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun Liu, MD, Doctor, Department of Psychiatry, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Number 43, Shangfang Road, Nanchang 330029, China. 13507914760@163.com
Received: July 10, 2024
Revised: September 3, 2024
Accepted: September 6, 2024
Published online: October 19, 2024
Processing time: 98 Days and 21.3 Hours
Core Tip

Core Tip: Diabetes mellitus and depression share a bidirectional relationship mediated by physiological mechanisms like inflammation and oxidative stress, compounded by psychosocial factors such as social support and lifestyle choices. Effective management necessitates integrated approaches that incorporate mental health assessments and personalized treatments. Future research should emphasize longitudinal and multi-omics studies to deepen our understanding and refine therapeutic strategies for better patient outcomes.