Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Aug 19, 2023; 13(8): 524-532
Published online Aug 19, 2023. doi: 10.5498/wjp.v13.i8.524
Pilot study of genome-wide DNA methylation and gene expression for treatment response to escitalopram in panic disorder
Zhi-Li Zou, Yuan Zhang, Yu-Lan Huang, Jin-Yu Wang, Bo Zhou, Hua-Fu Chen
Zhi-Li Zou, Yu-Lan Huang, Jin-Yu Wang, Bo Zhou, Hua-Fu Chen, Department of Psychosomatic Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China
Yuan Zhang, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China
Author contributions: Zou ZL was responsible for methodology, writing-original draft, funding acquisition, participants recruitment, blood sample collection, and data curation; Zhang Y was responsible for data curation, formal analysis; Huang YL and Wang JY was responsible for participants recruitment; Zhou B and Chen HF was responsible for conceptualization and participants recruitment.
Supported by The Sichuan Provincial People’s Hospital Translational Medicine Fund, No. 2021LY02.
Institutional review board statement: The study was approved by the Sichuan Provincial People’s Hospital ethics committee, reference number: (2021) Ethics Review (313).
Informed consent statement: All individuals provided written informed consent prior to the initiation of study procedures.
Conflict-of-interest statement: The authors report no conflict of interest.
Data sharing statement: The data used and analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hua-Fu Chen, PhD, Professor, Department of Psychosomatic Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No.32 West Second Section First Ring Road, Chengdu 611731, Sichuan Province, China.
Received: May 17, 2023
Peer-review started: May 17, 2023
First decision: July 4, 2023
Revised: July 5, 2023
Accepted: July 27, 2023
Article in press: July 27, 2023
Published online: August 19, 2023
Core Tip

Core Tip: No genome-wide methylation studies or mRNA sequencing have been conducted to identify early response biomarkers in patients with panic disorder (PD). This study aimed to compare genome-wide methylation and gene expression patterns between responsive and non-responsive patients with PD after 4 wk of escitalopram treatment. A total of 701 differentially methylated positions (DMPs) were found between responders and non-responders, and the hyper- and hypomethylated CpG sites were 511 (72.9%) and 190 (27.1%), respectively. This preliminary study showed that DMPs might be associated with the treatment response to escitalopram in PD.