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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jun 19, 2023; 13(6): 386-396
Published online Jun 19, 2023. doi: 10.5498/wjp.v13.i6.386
Published online Jun 19, 2023. doi: 10.5498/wjp.v13.i6.386
Abnormal volumetric brain morphometry and cerebral blood flow in adolescents with depression
Yu-Jia Fu, Xiao Liu, Xing-Yu Wang, Wen-yu Ren, Ren-Qiang Yu, Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Xiao Li, Lin-Qi Dai, Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Yong-Ming Zeng, Department of Radiology, Chongqing HongRen Yi Hospital, Chongqing 408400, China
Zhen-Lin Li, Department of Radiology, West China Hospital, Chengdu 610041, Sichuan Province, China
Author contributions: Fu YJ and Liu X contributed to writing the original draft; Fu YJ and Liu X contributed to the work equally; Liu X, Wang XY, and Ren WY contributed to scanning magnetic resonance imaging data; Liu X analyzed the data; Li X and Dai LQ contributed to investigation; Zeng YM and Li ZL contributed to conceptualization and checking the data; Yu RQ contributed to methodology, and writing – review, and editing; All authors contributed to the article and approved the submitted version.
Supported by The Project of Scientific Research and Innovative Experiment for College Students in Chongqing Medical University , No. 202215 ; and the Provincial Project of University Students Innovation and Entrepreneurship Training Program , No. 202210631015 .
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Chongqing Medical University Institutional Review Board, No. 20214801.
Informed consent statement: The legal guardians of all participants provided written informed consent, and all participants were provided with a comprehensive overview of the details of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at yurenqiang@hospital.cqmu.edu.cn . Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ren-Qiang Yu, Doctor, Doctor, Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Yixueyuan Road, Yuzhong District, Chongqing 400016, China. yurenqiang@hospital.cqmu.edu.cn
Received: March 31, 2023
Peer-review started: March 31, 2023
First decision: May 9, 2023
Revised: May 15, 2023
Accepted: May 24, 2023
Article in press: May 24, 2023
Published online: June 19, 2023
Processing time: 80 Days and 5 Hours
Peer-review started: March 31, 2023
First decision: May 9, 2023
Revised: May 15, 2023
Accepted: May 24, 2023
Article in press: May 24, 2023
Published online: June 19, 2023
Processing time: 80 Days and 5 Hours
Core Tip
Core Tip: In this study, we first combined cerebral blood flow (CBF) and voxel-based morphometry (VBM) to study brain alterations in adolescent depression. We also found that the brain function (CBF) changes were mainly in the left pallidum and right precentral gyrus. Meanwhile, we detected alterations in the cerebellum. Our finding about a wide range of brain structure (VBM) changes in adolescent depression contributes to better treatment and prevention strategies for depression.