Case Control Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Dec 19, 2023; 13(12): 985-994
Published online Dec 19, 2023. doi: 10.5498/wjp.v13.i12.985
Diagnostic and prognostic implications of non-high-density lipoprotein cholesterol and homocysteine levels for cognitive impairment in thalamic infarction
Shan-Yao Zhu, Wei Ge, Huan Zhang
Shan-Yao Zhu, Wei Ge, Huan Zhang, Department of Internal Medicine-Neurology, Chaohu Hospital Affiliated to Anhui Medical University, Hefei 238000, Anhui Province, China
Author contributions: Zhu SY and Zhang H conceived and designed the study; Zhu SY and Ge W guided the study; Zhu SY and Zhang H collected the clinical date; Zhu SY and Zhang H analyzed the data; All authors drafted and revised the manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Chaohu Hospital Affiliated to AnhuiMedical University, Approval No. KYXM-202208-011.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shan-Yao Zhu, Doctor, Chief Physician, Department of Internal Medicine-Neurology, Chaohu Hospital Affiliated to Anhui Medical University, No. 64 Chaohu North Road, Hefei 238000, Anhui Province, China. zsydoc@126.com
Received: September 14, 2023
Peer-review started: September 14, 2023
First decision: October 8, 2023
Revised: November 6, 2023
Accepted: December 2, 2023
Article in press: December 2, 2023
Published online: December 19, 2023
Core Tip

Core Tip: This study explored the diagnostic and prognostic implications of non-high-density lipoprotein cholesterol (non-HDL-C) and Homocysteine (Hcy) levels for cognitive impairment in patients with thalamic infarction. Both non-HDL-C and Hcy levels were found to be useful for the diagnosis of cognitive dysfunction in patients with thalamic infarction, with their combined detection being more effective. In addition, clinical precautions can be formulated based on their levels to prevent poor prognosis and reduce mortality.