Li Y, Yan JJ, Cui YH. Clinical characteristics of pediatric patients with treatment-refractory Tourette syndrome: An evidence-based survey in a Chinese population. World J Psychiatry 2022; 12(7): 958-969 [PMID: 36051602 DOI: 10.5498/wjp.v12.i7.958]
Corresponding Author of This Article
Yong-Hua Cui, MD, Chief Doctor, Department of Psychiatry, Beijing Children's Hospital, No. 56 Nanlishi Road, Beijing 100045, China. cuiyonghua@bch.com.cn
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Jul 19, 2022; 12(7): 958-969 Published online Jul 19, 2022. doi: 10.5498/wjp.v12.i7.958
Clinical characteristics of pediatric patients with treatment-refractory Tourette syndrome: An evidence-based survey in a Chinese population
Ying Li, Jun-Juan Yan, Yong-Hua Cui
Ying Li, Jun-Juan Yan, Yong-Hua Cui, Department of Psychiatry, Beijing Children's Hospital, Beijing 100045, China
Author contributions: Li Y and Yan JJ contribute equally to this study; Cui YH and Li Y took the initiative; Yan JJ participated in the data collection; Li Y performed the data analysis; Yan JJ finished the draft; all authors have read and approved the manuscript.
Supported bythe National Natural Science Foundation of China (NSFC), No. 82171538; and the Beijing Natural Science Foundation, No. 7212035.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Beijing Children’s Hospital (No. 2021-82171538).
Conflict-of-interest statement: All other authors report no conflict of interest for this article.
Data sharing statement: Data is available upon reasonable request for clearly defined scientific purposes from the corresponding author at cuiyonghua@bch.com.cn.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: December 21, 2021 Peer-review started: December 21, 2021 First decision: March 13, 2022 Revised: April 6, 2022 Accepted: June 27, 2022 Article in press: June 27, 2022 Published online: July 19, 2022 Processing time: 210 Days and 2.7 Hours
Core Tip
Core Tip: This study provides important evidence of treatment-refractory Tourette syndrome (TS) among Chinese patients due to the current shortage of studies based on Chinese samples. We found that the onset age of pediatric patients with treatment-refractory TS (TRTS) might be younger, and they might have a longer duration of illness, a lower intelligence quotient, and a higher premonitory urge, which often fluctuate due to psychosocial factors. Moreover, TRTS children might suffer more emotional and behavioral problems including social communication deficits (such as uncommunicative and social withdrawal), attention deficit hyperactivity disorder-related symptoms (hyperactive, aggressive, and delinquent), and obsessive-compulsive symptoms. These were the basic clinical characteristics of TRTS based on Chinese pediatric patients. Unravelling these clinical characteristics is beneficial for the early diagnosis and treatment of TRTS.
