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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2022; 12(7): 904-914
Published online Jul 19, 2022. doi: 10.5498/wjp.v12.i7.904
Published online Jul 19, 2022. doi: 10.5498/wjp.v12.i7.904
ABCB9 polymorphism rs61955196 is associated with schizophrenia in a Chinese Han population
Xin-Wei Li, Zhi-Jun Li, Li-Zhe Ai, Meng-Di Jin, Ning-Ning Jia, Meng-Tong Xie, Yu-Qing Yang, Wei-Zhen Li, Lin Dong, Qiong Yu, Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China
Ming-Yuan Zhang, Department of Endemic Diseases and Parasitic Diseases Prevention, Yantai Center for Disease Control and Prevention, Yantai 264003, Shandong Province, China
Author contributions: Li XW and Zhang MY performed the majority of experiments and wrote the manuscript; Li ZJ and Ai LZ provided advices to the manuscript correction; Jin MD served as scientific advisor and participated in the collection of human material; Jia NN was involved in analytical tools; Xie MT, Yang YQ, Li WZ and Dong L participated in the collection of the human material; Yu Q designed the study and is the guarantor; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China , No. 81673253 ; and Jilin Provincial Ministry of Education S&T Project , No. JJKH20190091KJ .
Institutional review board statement: The study was approved by the Ethics Committee of the School of Public Health of Jilin University (No. 2014-03-11).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author Qiong Yu upon reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiong Yu, MD, PhD, Professor, Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, Chaoyang District, Changchun 130021, Jilin Province, China. yuqiong@jlu.edu.cn
Received: January 28, 2022
Peer-review started: January 28, 2022
First decision: April 18, 2022
Revised: May 2, 2022
Accepted: June 17, 2022
Article in press: June 17, 2022
Published online: July 19, 2022
Processing time: 171 Days and 17.6 Hours
Peer-review started: January 28, 2022
First decision: April 18, 2022
Revised: May 2, 2022
Accepted: June 17, 2022
Article in press: June 17, 2022
Published online: July 19, 2022
Processing time: 171 Days and 17.6 Hours
Core Tip
Core Tip: Prenatal famine exposure may cause changes in DNA methylation levels of genes, while maternal nutrition is a pivotal environmental factor for schizophrenia (SCZ). To analyze the association between prenatal famine exposure and SCZ risk, we recruited 443 SCZ patients and 511 healthy controls with four single-nucleotide polymorphisms genotyped, which were previously identified as DNA methylation quantitative trait loci. Our study observed significant differences in rs61955196 genotype distribution and allele frequency between SCZ patients and healthy controls for the first time, suggesting that rs61955196 in ABCB9 was associated with SCZ susceptibility among the Northeast Han Chinese population.