Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. May 19, 2022; 12(5): 770-772
Published online May 19, 2022. doi: 10.5498/wjp.v12.i5.770
Biological mechanisms and possible primary prevention of depression
Chih-Yun Kuo, Ivo Stachiv
Chih-Yun Kuo, Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University, Prague 12108, Czech Republic
Ivo Stachiv, Department of Functional Materials, Institute of Physics, Czech Academy of Sciences, Praha 18021, Czech Republic
Author contributions: Both authors have prepared the manuscript, and contributed equally to this work.
Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ivo Stachiv, PhD, Academic Fellow, Associate Professor, Department of Functional Materials, Institute of Physics, Czech Academy of Sciences, Na Slovance 2, Praha 18021, Czech Republic. stachiv@fzu.cz
Received: December 7, 2021
Peer-review started: December 7, 2021
First decision: March 13, 2022
Revised: March 15, 2022
Accepted: April 26, 2022
Article in press: April 26, 2022
Published online: May 19, 2022
Processing time: 161 Days and 9.7 Hours
Core Tip

Core Tip: Dietary interventions, especially Mediterranean diet, may help to reduce the risk for development of depression. It is the high levels of various antioxidant compounds, adequate B-group vitamin and folate content which make the Mediterranean diet a possible candidate for an inexpensive primary intervention of depression. However, the long-term clinical trials on the large cohorts are still necessary to understand the relationship between dietary pattern and development of depression or dementia.