Observational Study
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World J Psychiatry. Mar 19, 2022; 12(3): 470-482
Published online Mar 19, 2022. doi: 10.5498/wjp.v12.i3.470
Studying the relationship between clinical features and mental health among late-onset myasthenia gravis patients
Lu Yu, Li Qiu, Hao Ran, Qian Ma, Ya-Ru Lu, Wei-Bin Liu
Lu Yu, Li Qiu, Qian Ma, Ya-Ru Lu, Wei-Bin Liu, Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Hao Ran, School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, China
Author contributions: Liu WB was the guarantor and contributed to the conception of the study; Yu L and Qiu L participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Ran H, Ma Q, Lu YR revised the article critically for important intellectual content.
Supported by the National Natural Science Foundation of China, No. 81873772 and 81971754; National Natural Science Foundation Key International (Regional) Cooperation Research Project, No. 81620108010; Clinical Study of 5010 Planned Project Sun Yat-sen University, No. 2010003; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, No. 2020B1212060017; Guangdong Provincial Clinical Research Center for Neurological Diseases, No. 2020B1111170002; the Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases, No. 2015B050501003 and 2020A0505020004.
Institutional review board statement: This study was reviewed and approved by the ethics committee of The First Affiliated Hospital of the Sun Yat-sen University.
Informed consent statement: All study participants provided informed written consent prior to the scale-based clinical examinations.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Bin Liu, MD, Chief Physician, Professor, Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, the First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou 510080, Guangdong, China. liuwb@mail.sysu.edu.cn
Received: August 1, 2021
Peer-review started: August 1, 2021
First decision: December 4, 2021
Revised: November 26, 2021
Accepted: February 22, 2022
Article in press: February 22, 2022
Published online: March 19, 2022
Processing time: 229 Days and 7.9 Hours
Core Tip

Core tip: Mental disorders are the common comorbidities among myasthenia gravis (MG) patients in older age. In this study, we found that female patients with late-onset MG were more susceptible to anxiety and depression than their male counterparts, and that higher scores on the Myasthenia Gravis Quality of Life 15 questionnaire were an independent risk factor for anxiety and depression in patients with late-onset MG. This is the first report detailing the relationship between clinical features and mental health in the subgroup of MG patients with late disease onset.