Parmar S, Tadavarty R, Sastry BR. G-protein coupled receptors and synaptic plasticity in sleep deprivation. World J Psychiatr 2021; 11(11): 954-980 [PMID: 34888167 DOI: 10.5498/wjp.v11.i11.954]
Corresponding Author of This Article
Bhagavatula R Sastry, PhD, Professor, Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver V6T 1Z3, British Columbia, Canada. sastry@interchange.ubc.ca
Research Domain of This Article
Neurosciences
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatr. Nov 19, 2021; 11(11): 954-980 Published online Nov 19, 2021. doi: 10.5498/wjp.v11.i11.954
G-protein coupled receptors and synaptic plasticity in sleep deprivation
Shweta Parmar, Ramakrishna Tadavarty, Bhagavatula R Sastry
Shweta Parmar, Ramakrishna Tadavarty, Bhagavatula R Sastry, Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver V6T 1Z3, British Columbia, Canada
Author contributions: Parmar S, Tadavarty R and Sastry BR contributed equally to the outline of this review; Parmar S performed 85% of the writing work, and Tadavarty R performed 15%; Illustrations were done by Parmar S; Suggestions and corrections were contributed by Sastry BR; All authors have read and approved the manuscript.
Supported byCanadian Institutes of Health Research Grant, No. TGS-109219; and 4-Year Fellowship from the University of British Columbia.
Conflict-of-interest statement: Authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bhagavatula R Sastry, PhD, Professor, Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver V6T 1Z3, British Columbia, Canada. sastry@interchange.ubc.ca
Received: February 25, 2021 Peer-review started: February 25, 2021 First decision: May 13, 2021 Revised: June 5, 2021 Accepted: September 19, 2021 Article in press: September 19, 2021 Published online: November 19, 2021 Processing time: 264 Days and 4.8 Hours
Core Tip
Core Tip: Sleep hygiene is thought to be necessary for memory consolidation and learning while sleep disturbances can alter both synaptic plasticity and memory consolidation. Recent findings indicate that the expression of G-protein coupled receptors (GPCRs) like metabotropic glutamate receptors, gamma-amino butyric acid-B receptors and serotonin (5-hydroxytryptamine) receptors as well as synaptic plasticity are altered following a short episode of sleep deprivation. GPCRs are involved in a variety of central nervous system functions and are targets for therapeutic agents in psychiatry and other neurological disorders. Therefore, a deeper understanding of these receptors in association with the state of sleep and its related functions and disorders is needed.
