Observational Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Nov 19, 2020; 10(11): 260-271
Published online Nov 19, 2020. doi: 10.5498/wjp.v10.i11.260
Testing the hypothesis of subtypes of nonadherence in schizophrenia and schizoaffective disorder: A prospective study
Dulcinea Vega, Francisco J Acosta, Pedro Saavedra
Dulcinea Vega, Department of Psychiatry, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria 35016, Las Palmas, The Canary Islands, Spain
Dulcinea Vega, Francisco J Acosta, Department of Psychiatry, Insular University Hospital of Gran Canaria, Las Palmas de Gran Canaria 35016, Las Palmas, The Canary Islands, Spain
Francisco J Acosta, Department of Mental Health General Management of Healthcare Programs, Canary Islands Health Service, Las Palmas de Gran Canaria 35004, Las Palmas, The Canary Islands, Spain
Francisco J Acosta, Research Network on Health Services for Chronic Conditions (REDISSEC), Carlos III Health Institute, Madrid 28029, Spain
Pedro Saavedra, Department of Mathematics, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria 35016, Las Palmas, The Canary Islands, Spain
Author contributions: Acosta FJ designed the study and wrote the protocol, wrote the first draft of the manuscript, and coordinated the project; Vega D managed the literature searches and was in charge of the recruitment and assessments of all patients; Saavedra P was in charge of data management and undertook the statistical analysis; and all authors contributed to and have approved the final manuscript.
Supported by College of Physicians of Las Palmas, No. I03/19.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Insular University Hospital of Gran Canaria, Approval No. CEIm-CHUIMI-2016/893.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Francisco J Acosta, MD, PhD, Doctor, Department of Mental Health General Management of Healthcare Programs, Canary Islands Health Service, Las Palmas de Gran Canaria 35004, Las Palmas, The Canary Islands, Spain. fjacostaartiles@hotmail.com
Received: August 4, 2020
Peer-review started: August 4, 2020
First decision: September 21, 2020
Revised: October 2, 2020
Accepted: October 20, 2020
Article in press: October 20, 2020
Published online: November 19, 2020
Processing time: 103 Days and 21.6 Hours
Core Tip

Core Tip: Nonadherence is a major problem in the treatment of psychotic disorders. The scarcity of consistently identified variables associated with nonadherence could be due, at least in part, to real heterogeneity among nonadherent patients. Although in recent years the existence of two main subtypes according to intentionality has been hypothesized, no previous studies have specifically tested this hypothesis. This research aimed to fill this gap. We found differentiated profiles in nonadherent patients according to intentionality. Our results support the nonadherence subtypes hypothesis in psychotic disorders.