Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Apr 19, 2024; 14(4): 513-522
Published online Apr 19, 2024. doi: 10.5498/wjp.v14.i4.513
Clarifying the relationship and analyzing the influential factors of bronchial asthma in children with attention-deficit hyperactivity disorder
Gui-Xia Wang, Xiao-Ying Xu, Xi-Qing Wu
Gui-Xia Wang, Department of Infectious Diseases, Dongying People’s Hospital, Dongying 257000, Shandong Province, China
Xiao-Ying Xu, Department of Children's Health, Dongying People’s Hospital, Dongying 257000, Shandong Province, China
Xi-Qing Wu, Department of Children's Health, Shengli Oilfield Central Hospital, Dongying 257000, Shandong Province, China
Author contributions: Wang GX and Xu XY initiated the project, designed the experiment and conducted clinical data collection; Wu XQ performed postoperative follow-up and recorded data; Wang GX and Xu XY conducted a number of collation and statistical analysis, and wrote the original manuscript.; all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Dongying People’s Hospital, and the ethics committee agreed to waive informed consent.
Informed consent statement: After review by the Ethics Committee, a waiver of informed consent was granted for this subject.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gui-Xia Wang, Associate Chief Physician, Department of Infectious Diseases, Dongying People’s Hospital, No. 317 Dongcheng South 1st Road, Dongying 257000, Shandong Province, China. wangguixia710525@163.com
Received: January 25, 2024
Peer-review started: January 25, 2024
First decision: February 8, 2024
Revised: February 22, 2024
Accepted: March 7, 2024
Article in press: March 7, 2024
Published online: April 19, 2024
Processing time: 82 Days and 22.6 Hours
ARTICLE HIGHLIGHTS
Research background

The relationship between bronchial asthma and attention-deficit hyperactivity disorder (ADHD) in children and its pathogenesis have become a hot and difficult issue in the field of pediatrics. The latest large sample report based on the population confirmed that ADHD can be associated with a variety of allergic diseases, including bronchial asthma, but the specific relationship between the two and the related risk factors are unknown. Therefore, this study intends to preliminarily analyze the relationship between ADHD and asthma, and analyze the related risk factors, in order to further understand the relationship between them, avoid the exposure of related risk factors of bronchial asthma and ADHD children to reduce the risk of disease. In order to better clinical management of children with asthma and ADHD.

Research motivation

This study mainly analyzes the association between childhood asthma and ADHD and related risk factors, which is of great significance for the individualized clinical comprehensive management of these two diseases, and is helpful for clinical prevention and treatment according to the exposure of related risk factors.

Research objectives

This study mainly expounds the relationship between childhood asthma and ADHD. Individualized intervention measures for risk factors can effectively reduce the risk of asthma, and provide reference for the prevention and treatment of the pathogenesis of the two in the future.

Research methods

In this study, a retrospective study was conducted to collect the clinical data and parental data of all selected children. Multivariate logistic regression analysis was used to analyze the risk factors of comorbid asthma in children with ADHD. Multivariate logistic regression analysis has the advantages of controllable covariate effect, model flexibility, and consideration of interaction, which can better and more comprehensively understand and explain the changes of dependent variables.

Research results

The results of this study found that ADHD children are more likely to suffer from asthma than healthy control children. Family history of asthma, adverse factors of mother during pregnancy, and parental relationship are all factors affecting the risk of comorbidity of asthma in ADHD children. Targeted interventions can be taken to reduce the risk of comorbidity of asthma. However, this study is a retrospective study, and the sample size is small, which may cause some bias to the research results. In the future, the sample size will be expanded to analyze the specific pathogenesis of ADHD children with asthma.

Research conclusions

Through retrospective cohort study, this study further confirmed that ADHD children are more likely to suffer from asthma than healthy control children, and ADHD children are more likely to suffer from asthma than healthy control children, which is an important factor affecting the comorbidity of the two diseases.

Research perspectives

In the follow-up study, the sample size will be further increased, and the specific pathogenesis of bronchial asthma will be analyzed according to the different clinical subtypes of ADHD.