Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2023; 13(7): 478-485
Published online Jul 19, 2023. doi: 10.5498/wjp.v13.i7.478
Role of comprehensive geriatric assessment in screening for mild cognitive disorders
Jie Yu, Shou-Rong Lu, Zhuo Wang, Yin Yang, Bin-Shan Zhang, Qiao Xu, Hong Kan
Jie Yu, Shou-Rong Lu, Zhuo Wang, Yin Yang, Bin-Shan Zhang, Qiao Xu, Hong Kan, Department of Geriatrics, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu Province, China
Author contributions: Yu J and Lu SR contributed equally to this work; Wang Z, Yang Y designed the research study; Zhang BS performed the research; Hong K contributed new reagents and analytic tools; Xu Q analyzed the data and wrote the manuscript; and all authors have read and approve the final manuscript.
Supported by Jiangsu Provincial Elderly Health Research Project, No. LR2021020, No, LD2021016; Major Project of Wuxi Municipal Health Commission, No. Z202002; Scientific Research Project of Jiangsu Provincial Health Commission, No. BJ21008.
Institutional review board statement: The research plan has been reviewed by the Ethics Committee of Wuxi People's Hospital.
Informed consent statement: All patients have signed informed consent forms.
Conflict-of-interest statement: None conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong Kan, PhD, Chief Physician, Department of Geriatrics, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, China. 2898456291@qq.com
Received: March 22, 2023
Peer-review started: March 22, 2023
First decision: April 10, 2023
Revised: May 16, 2023
Accepted: June 21, 2023
Article in press: June 21, 2023
Published online: July 19, 2023
Processing time: 118 Days and 3 Hours
ARTICLE HIGHLIGHTS
Research background

Comprehensive geriatric assessment (CGA) is a multidisciplinary approach that assesses the physical health, functional status, mental health and social-environmental status of older people. CGA can facilitate timely treatment, slow down the disease process and reduce dementia through multidimensional analysis of Mild cognitive impairment.

Research motivation

This study found that CGA allows accurate identification of mild cognitive impairment with high sensitivity and specificity, facilitating timely and effective intervention.

Research objectives

This study was conducted to evaluate the role of comprehensive geriatric assessment in screening for mild cognitive disorders.

Research methods

Using Petersen as the diagnostic gold standard, healthy individuals were included in the control group and patients with mild cognitive impairment were assigned to the study group. The correlation between the cognitive function of the patients and their baseline clinical profiles was analysed. Patients' Montreal Cognitive Assessment (MoCA) and CGA screening results were compared, and the sensitivity and specificity were calculated to assess the screening role of CGA.

Research results

CGA assessment yielded higher diagnostic accuracy than MoCA. The results of the multivariate regression analysis showed no correlation of gender, age, body mass index and literacy with cognitive function. Patients with mild cognitive impairment obtained significantly lower MoCA scores than healthy individuals. In the CGA scale, patients with mild cognitive impairment showed significantly lower Mini-mental State Examination, Miniature Nutritional Assessment and Berg Balance Scale scores, and higher Activity of Daily Living, Instrumental Activities of Daily Living Scale and FRAIL scores than healthy individuals. The CGA provides higher diagnostic sensitivity and specificity than the MoCA.

Research conclusions

CGA allows accurate identification of mild cognitive impairment with high sensitivity and specificity, facilitating timely and effective intervention, and is thus recommended for clinical use.

Research perspectives

Future studies will expand the sample to further improve the protocol and provide more references for future relevant diagnostic treatments.