Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Dec 19, 2023; 13(12): 1027-1036
Published online Dec 19, 2023. doi: 10.5498/wjp.v13.i12.1027
Efficacy of enhanced extracorporeal counterpulsation combined with atorvastatin in the treatment of cognitive impairment after stroke
Yan Duan, Hui-Xia Tang
Yan Duan, Hui-Xia Tang, Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Author contributions: Duan Y initiated the project, designed the experiment and conducted clinical data collection; Tang HX performed postoperative follow-up and recorded data, conducted a number of collation and statistical analysis, and wrote the original manuscript; both authors reviewed and approved the paper; and all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Shengjing Hospital of China Medical University.
Informed consent statement: The ethics committee waived the requirement for informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Xia Tang, MM, Nurse, Department of Rehabilitation, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110000, Liaoning Province, China. 18940258255@163.com
Received: September 12, 2023
Peer-review started: September 12, 2023
First decision: September 25, 2023
Revised: October 20, 2023
Accepted: November 8, 2023
Article in press: November 8, 2023
Published online: December 19, 2023
Processing time: 98 Days and 4.2 Hours
ARTICLE HIGHLIGHTS
Research background

The research background is the discussion on the treatment of patients with cognitive dysfunction after stroke. The current research status is that atorvastatin is widely used to treat cognitive impairment after stroke, and the research significance is to provide a new treatment plan for cognitive impairment after stroke and improve clinical efficacy.

Research motivation

With the treatment of stroke patients with cognitive dysfunction as the research topic, more effective treatment plans need to be explored to improve the prognosis of stroke patients with cognitive dysfunction. The significance of this study is to affirm the better treatment of cerebral stroke patients with cognitive dysfunction, and promote the innovation of clinical treatment of cerebral stroke cognitive endometrial methods.

Research objectives

The objective of this study was to compare the therapeutic effect of different treatment methods and to observe the advantages of enhanced external counterpulsation (EECP) combined with atorvastatin over atorvastatin alone. In this study, enhanced in vitro rebuttal combined with atorvastatin was effective in the treatment of cognitive dysfunction in stroke patients, including cognitive function, ability of daily living, vascular endothelial function, nerve function and cerebral blood flow, confirming that the combined treatment has good clinical effects and providing a new reference for the treatment of cognitive dysfunction in stroke patients in the future.

Research methods

The clinical data of the patients were analyzed retrospectively and grouped according to different treatment methods. Then, independent sample t test, paired sample t test and χ2 test were used to statistically analyze the general data of the two groups, including mental state, cognitive function, daily living ability score, neurotransmitter level, vascular endothelial function index level, cognitive-related index and cerebral blood flow index before and after treatment. The feature of retrospective study is to explore the cause through the results, and it is easier to obtain the case data.

Research results

EECP combined with atorvastatin can significantly improve cognitive function, mental state, ability of daily living, vascular endothelial function, nerve function and cerebral blood flow in the treatment of stroke patients with cognitive dysfunction, which provides a new treatment method for the treatment of stroke patients with cognitive dysfunction and requires further prospective exploration. To further verify the effectiveness of this treatment method.

Research conclusions

Vascular endothelial dysfunction can lead to impairment of the blood-brain barrier, leading to cognitive dysfunction. Therefore, attention should be paid to the effect of treatment on vascular endothelial function. Based on the better treatment effect of EECP combined with atorvastatin, the more effective treatment scheme should be selected in clinic.

Research perspectives

Biological indicators can effectively reflect the severity of the patient’s disease, and the effect of treatment regimen on the level of novel biomarkers in patients with post-stroke cognitive dysfunction needs to be further explored.