Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2023; 13(11): 872-883
Published online Nov 19, 2023. doi: 10.5498/wjp.v13.i11.872
Analysis of the relationship between blood pressure variability and subtle cognitive decline in older adults
Hui-Feng Guo, Yi Wu, Jie Li, Feng-Feng Pan
Hui-Feng Guo, Jie Li, Feng-Feng Pan, Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
Yi Wu, Prenatal Diagnosis Center, International Peace Maternity & Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
Co-corresponding authors: Hui-Feng Guo and Yi Wu.
Author contributions: HF Guo and Y Wu analyzed the data and wrote the paper; Li J was responsible for execution and data collection; Pan FF was responsible for the study conception and design; the final version of the manuscript has been approved by all authors. Guo HF and Wu Y contributed equally to this work as co-corresponding authors. The reasons for designating them as co-corresponding authors are as follows: Firstly, this manuscript is a collaborative work. The designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. Secondly, Guo HF and Wu Y contributed equally to this work. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. Guo HF is responsible for the overall planning and the organization of clinical data, Wu Y is responsible for the data summary and statistical analysis. In summary, we believe that designating Guo HF and Wu Y as co-corresponding authors of is fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.
Supported by Shanghai Municipal Commission of Science and Technology Program, No. 19411960900.
Institutional review board statement: The study was reviewed and approved by the Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, approval No. 2022-0326.
Informed consent statement: All study participants provided written informed consent for personal and medical data collection prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The dataset is available from the corresponding author at ghfghm@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Feng Guo, MM, Associate Chief Physician, Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Xuhui District, Shanghai 200233, China. ghfghm@163.com
Received: August 30, 2023
Peer-review started: August 30, 2023
First decision: September 13, 2023
Revised: September 18, 2023
Accepted: October 23, 2023
Article in press: October 23, 2023
Published online: November 19, 2023
Processing time: 79 Days and 0.6 Hours
ARTICLE HIGHLIGHTS
Research background

Cognitive impairment is a highly harmful disease for which there is no perfect treatment. Early detection and treatment are the main focus of related research. Variation in blood pressure has been correlated with cognitive impairment in previous studies; however, few studies have examined subtle cognitive decline.

Research motivation

Our purpose was to analyze the influencing factors for subtle cognitive decline (SCD) and find a simple and effective index through which to assess cognitive decline that can be used to guide clinical work.

Research objectives

The study aimed to determine whether blood pressure variability (BPV) leads to cognitive impairment. The results showed that an increase in BPV is independently related to SCD and that BPV may be used as a tool for evaluating cognitive impairment and the effectiveness of treatment.

Research methods

We used a standard neuropsychological scale to evaluate cognitive function and retrospectively analyzed the correlation between BPV and SCD.

Research results

The results show that increased BPV may be a factor leading to cognitive decline. The results of such studies are rare; however, the sample size is not sufficiently large, and no further research has been carried out to determine whether it can be used as an index to analyze the effectiveness of treatment.

Research conclusions

This study demonstrates that BPV is a clinical indicator of early cognitive decline. In this study, 24-h ambulatory blood pressure monitoring test was used as an index from which to calculate BPV, one that is simple, effective, and can be readily used in primary healthcare institutions.

Research perspectives

Long-term follow-ups should be considered in the future to further the collective comprehension of the correlation between BPV and cognitive decline and the progress of cognitive impairment as well as to estimate the benefits of improving BPV in the treatment of cognitive impairment.