Li XK, Qiu HT, Hu J, Luo QH. Changes in the amplitude of low-frequency fluctuations in specific frequency bands in major depressive disorder after electroconvulsive therapy. World J Psychiatry 2022; 12(5): 708-721 [PMID: PMC9150034 DOI: 10.5498/wjp.v12.i5.708]
Corresponding Author of This Article
Xin-Ke Li, PhD, Associate Professor, College of Medical Informatics, Chongqing Medical University, No. 1 Medical School Road, Chongqing 400016, China. lixinke@cqmu.edu.cn
Research Domain of This Article
Psychiatry
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. May 19, 2022; 12(5): 708-721 Published online May 19, 2022. doi: 10.5498/wjp.v12.i5.708
Changes in the amplitude of low-frequency fluctuations in specific frequency bands in major depressive disorder after electroconvulsive therapy
Xin-Ke Li, Hai-Tang Qiu, Jia Hu, Qing-Hua Luo
Xin-Ke Li, College of Medical Informatics, Chongqing Medical University, Chongqing 400016, China
Hai-Tang Qiu, Qing-Hua Luo, Mental Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing 400016, China
Jia Hu, Institute for Advanced Studies in Humanities and Social Science, Chongqing University, Chongqing 400044, China
Author contributions: Li XK conducted the statistical analysis and wrote the manuscript; Qiu HT performed the study design and interpretation of findings; Luo QH recruited the patients, collected the data; Hu J revised the manuscript.
Supported bythe Natural Science Foundation of China, No. 81901373; and the Intelligent Medicine Research Project of Chongqing Medical University, No. ZHYX202126.
Institutional review board statement: The study was reviewed and approved by the (the local ethics committee of Chongqing Medical University) Institutional Review Board (Approval No. 2020-97-2).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have no conflict interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Ke Li, PhD, Associate Professor, College of Medical Informatics, Chongqing Medical University, No. 1 Medical School Road, Chongqing 400016, China. lixinke@cqmu.edu.cn
Received: December 22, 2021 Peer-review started: December 22, 2021 First decision: March 13, 2022 Revised: March 26, 2022 Accepted: April 21, 2022 Article in press: April 21, 2022 Published online: May 19, 2022 Processing time: 146 Days and 15.8 Hours
ARTICLE HIGHLIGHTS
Research background
The mechanism of efficacy of electroconvulsive therapy (ECT) for major depressive disorder (MDD) is still unclear. Intrinsic functional activities of brain networks are correlated with different frequency bands.
Research motivation
The amplitude of low-frequency fluctuations (ALFF) at different frequency bands (slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.08 Hz)) in MDD patients may be changed regularly before and after ECT.
Research objectives
To investigate the alterations of the amplitude of low-frequency fluctuations in slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.08 Hz) in patients with MDD after ECT.
Research methods
Resting-state functional magnetic resonance imaging and the intrinsic neural oscillations in different bands were adopted to analyze the changes in MDD patients before and after ECT.
Research results
Compared to before ECT, we found that MDD patients after ECT had a higher ALFF in the typical band in some regions such as the right middle frontal gyrus and posterior cingulate. Moreover, there were other changes in slow-5 band and slow-4 band.
Research conclusions
Our findings showed that the ALFF alterations in post-ECT patients were dependent on specific frequency bands.
Research perspectives
These changes may reveal some mechanism of efficacy of electroconvulsive therapy for major depressive disorder.
