Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.18
Peer-review started: September 1, 2015
First decision: November 6, 2015
Revised: November 24, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: March 22, 2016
Processing time: 201 Days and 7.4 Hours
The brain is a complex network system that has the capacity to support emotion, thought, action, learning and memory, and is characterized by constant activity, constant structural remodeling, and constant attempt to compensate for this remodeling. The basic insight that emerges from complex network organization is that substantively different networks can share common key organizational principles. Moreover, the interdependence of network organization and behavior has been successfully demonstrated for several specific tasks. From this viewpoint, increasing experimental/clinical observations suggest that mental disorders are neural network disorders. On one hand, single psychiatric disorders arise from multiple, multifactorial molecular and cellular structural/functional alterations spreading throughout local/global circuits leading to multifaceted and heterogeneous clinical symptoms. On the other hand, various mental diseases may share functional deficits across the same neural circuit as reflected in the overlap of symptoms throughout clinical diagnoses. An integrated framework including experimental measures and clinical observations will be necessary to formulate a coherent and comprehensive understanding of how neural connectivity mediates and constraints the phenotypic expression of psychiatric disorders.
Core tip: Increasing evidences suggest that mental diseases are neural network disorders. Neurites and synapses represent the sub-cellular elements organizing these networks, and the molecules that regulate their formation, retraction and adaptive remodeling may contribute to the pathology of mental disorders. Various syndromes may share alterations of functional network leading to symptoms overlapping through clinical diagnoses.